Brain zapping tailored to you: new study targets depression and anxiety
NCT ID NCT05437705
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study at the University of Pennsylvania is testing whether personalized brain stimulation can reduce negative emotions in people with depression and anxiety. Researchers will use brain scans to map each participant's negative emotion patterns, then apply different types of transcranial magnetic stimulation (TMS) to find the best frequency for disrupting those patterns. The goal is to see if the optimal stimulation can improve symptoms like rumination over two 3-day sessions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Transcranial Magnetic Stimulation (TMS)
What this could lead to
If successful, this could lead to a personalized brain stimulation treatment that reduces rumination and negative emotions in people with depression or anxiety.
What could go wrong
This is an early-stage study with only 40 participants, so results may not apply to everyone. The optimal stimulation frequency may not work better than the least optimal one.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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