Nasal spray could quickly calm anxiety in End-of-Life patients

NCT ID NCT06330584

Recruiting now Symptom relief Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether a midazolam nasal spray can quickly reduce acute anxiety in adults receiving palliative care. Participants will receive one of two doses of midazolam or a placebo spray. The main goal is to see if anxiety levels drop within 30 minutes, while also checking safety and how the drug moves through the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: midazolam nasal spray
What this could lead to: If it works, this could offer a fast, needle-free way to calm severe anxiety in people receiving end-of-life care.
What could go wrong: This is a very small early pilot study with only 36 participants, so results may not apply broadly. Midazolam can cause drowsiness or breathing problems, especially in frail patients.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE ANXIETY ANXIETY PALLIATIVE CARE

Contacts and locations

Locations

Inselspital, Universitätsspital Bern
NOT_YET_RECRUITING

Bern, 3010, Switzerland
Kompetenzzentrum Palliative Care, Universitätsspital Zürich
RECRUITING

Zurich, 8091, Switzerland
Palliativzentrum Bethesda Spital
RECRUITING

Basel, Canton of Basel-City, 4052, Switzerland
Universitäres Zentrum für Palliative Care (UZP)
RECRUITING

Bern, Switzerland
Zentrum für Palliative Care, Stadtspital Zürich
RECRUITING

Zurich, 8037, Switzerland

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