PALLIATIVE CARE

This study looks at whether high-flow nasal therapy can help relieve severe breathlessness in people receiving palliative care. About 40 patients will try both the nasal therapy and a fan blowing air on their face for 30 minutes each. Researchers will ask how their breathing feel…

This early-stage study tests a drug called resiniferatoxin (RTX), a chemical from a cactus-like plant similar to hot pepper, for people with severe cancer pain that standard treatments can't control. RTX is injected into the spine to destroy pain-transmitting nerves. The trial in…

This study looks at whether two simple relaxation methods—progressive muscle relaxation and deep breathing exercises—can reduce shortness of breath and severe tiredness in people with advanced cancer receiving palliative care. About 90 participants will be assigned to one of the …

This study tests whether low or moderate doses of LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either two moderate doses or two very low (placebo-like) doses of LSD in a double-blind setup. The goal is…

This study tests whether a structured, symptom-driven care pathway improves symptom control and satisfaction for adults with advanced cancer receiving outpatient palliative care. 120 participants will be randomly assigned to either standard care or a tailored pathway that trigger…

This study tests a mobile app called ICUconnect that helps older ICU patients and their families report their needs to doctors. The goal is to improve care and reduce emotional distress. About 350 patient-family pairs will take part across four hospitals.

This study tests whether giving testosterone injections every 15 days can improve quality of life for men with low testosterone who are receiving best supportive care and have no further treatment options. Researchers will track symptoms like pain, fatigue, and daily living activ…

This pilot study will test whether medicinal cannabis can help ease symptoms like pain, muscle spasms, and gut problems in 10 children (ages 6 months to 21 years) who are receiving palliative care for non-cancer conditions. The study focuses on whether the approach is practical a…

This study is testing a new program called POISE for people with stage IV non-small cell lung cancer who are on targeted therapy. The program includes four visits with a specially trained palliative care clinician to help patients cope with uncertainty and manage their cancer. Re…

This study tests a program to improve palliative care in intensive care units (ICUs). The program includes remote consultations with palliative care experts, training for ICU staff, and checklists to identify patients who need extra support. Researchers will track 2040 patients t…

This study tests whether using a virtual reality headset can help people receiving palliative care achieve personal goals, such as relaxation or bucket-list experiences. Up to 12 patients and their companions will try up to 3 VR sessions. Researchers will track mood, anxiety, and…

This study tests whether a midazolam nasal spray can quickly reduce acute anxiety in adults receiving palliative care. Participants will receive one of two doses of midazolam or a placebo spray. The main goal is to see if anxiety levels drop within 30 minutes, while also checking…

This study looks at whether palliative and supportive care, usually given to people near the end of life, could also help those with long-term inflammatory arthritis like rheumatoid arthritis. Researchers will interview patients and survey healthcare professionals to understand u…

This survey study explores how common oral health issues like dry mouth and infections are in palliative care patients, and how well healthcare professionals understand dental care. Researchers will ask patients and members of the German Society for Palliative Medicine about thei…

This study looks at how cancer patients in palliative care feel about stopping medications that are not for their cancer. About 120 participants will fill out questionnaires, watch an educational video, and receive a brochure. Researchers want to see if this information changes t…

This study looks at how people with advanced cancer feel about stopping or reducing medications that may no longer help. Researchers will interview about 25 patients and survey 300 more to understand their attitudes and beliefs. The goal is to learn what factors influence their v…

This study looks at whether adding a special care program (GRACE) to regular annual check-ups can help older adults with multiple health issues avoid hospital stays and feel better. About 6,000 people aged 65 and older who speak English or Spanish will take part. The goal is to s…

This study interviews staff and caregivers at two medicalized residential facilities in Alsace, France, to understand what helps or hinders creating care plans for vulnerable patients receiving palliative care. Researchers will analyze conversations to identify key factors like s…

This study tests a virtual training program called ABCs that teaches healthcare providers how to have better conversations with patients about serious illness. The program includes online modules and live workshops. Researchers will compare providers who receive the training righ…