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Magic Mushroom-Like drug tested for depression and anxiety

NCT ID NCT06820723

Recruiting now Knowledge-focused Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 4 times

Summary

This study will give 40 adults with major depression and moderate-to-severe anxiety a single dose of CYB003 (a synthetic version of psilocin, the active ingredient in magic mushrooms) or a placebo. Researchers will use brain scans (fMRI, EEG) and questionnaires to see how the drug affects brain activity and symptoms. The goal is to understand how psychedelics might help, not to prove a cure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
CYB003 (a synthetic version of psilocin, the active compound in magic mushrooms)
What this could lead to
If it works, this could help explain how psychedelics affect the brain in depression and anxiety, pointing toward new treatments.
What could go wrong
This is a small, early-phase study (40 people) focused on brain changes, not a proven treatment. The drug may not improve symptoms or could cause side effects like hallucinations or emotional distress.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY DEPRESSION MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

  • The Ohio State University Department of Psychiatry

    RECRUITING

    Columbus, Ohio, 43210, United States

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