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E-Cigs plus coaching may help mentally ill smokers cut harm

NCT ID NCT06543407

Recruiting now Disease control Sponsor: Dartmouth-Hitchcock Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren't ready to quit now. Participants either get e-cigarettes alone or e-cigarettes plus up to 10 coaching sessions over 8 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
e-cigarettes (NJOY brand) and behavioral support (SWITCH IT coaching)
What this could lead to
If it works, this could offer a practical way for smokers with mental illness who can't quit to reduce their health risks by switching to e-cigarettes.
What could go wrong
This is an early-stage study with 250 participants, so results may not apply to everyone. E-cigarettes are not risk-free, and long-term effects are still unknown.

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Conditions

The condition(s) this trial relates to.

anxiety disorder bipolar disorder Harm Reduction major depressive disorder nicotine dependence post-traumatic stress disorder schizophrenia Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOBACCO DEPENDENCE

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Seven Counties Services

    RECRUITING

    Louisville, Kentucky, 40203, United States

    Contact Email: •••••@•••••

    Contact Email: •••••@•••••

  • The Providence Center

    RECRUITING

    Providence, Rhode Island, 02903, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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