Dartmouth-hitchcock Medical Center

This study tests a new way to give chemotherapy for gastrointestinal cancers like colorectal and stomach cancer. Doctors will adjust the dose of one chemo drug (5-FU) based on how well each patient tolerates it, aiming to give higher doses to those who can handle it without sever…

This phase 2 study tests estradiol, a form of estrogen, in postmenopausal women with advanced ER+ breast cancer that has stopped responding to other hormone therapies. The goal is to see if patients with a specific genetic change (ESR1 mutation) benefit more than those without it…

This study tests whether adding a drug called tetrathiomolybdate (TM) to standard chemotherapy (capecitabine) can reduce the risk of cancer spreading in people with high-risk triple-negative breast cancer. The trial has two parts: first, a small safety phase, then a larger random…

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It is for those whose arm has not improved with rehab. The goal is to see if the surgery can improve arm movement and control.

This study tests a laser treatment for tumors that have spread to the spine. The goal is to see if the laser can control tumor growth as well as traditional surgery, but with less risk. About 25 people with spine tumors will receive the laser treatment and be followed with MRI sc…

This phase 2 study is testing several drug combinations (fulvestrant plus either neratinib, alpelisib, or everolimus) in 135 postmenopausal women with advanced ER+/HER2- breast cancer that has progressed after CDK4/6 inhibitor treatment. The goal is to see which combination offer…

This study tests whether giving e-cigarettes to smokers with mental illness—along with optional behavioral coaching—helps them switch from regular cigarettes and lower their exposure to harmful chemicals. The trial enrolls 250 daily smokers who have tried to quit before but aren'…

This study tests a new way of giving chemotherapy to people with pancreatic cancer that is on the edge of being removable. The goal is to shrink the tumor enough for successful surgery. About 35 adults will receive two different chemo drug combinations in alternating cycles. The …

This study compares two ways to monitor older adults (ages 65-82) who have had colon polyps in the past: an annual stool test (FIT) or a colonoscopy every few years. About 9,000 participants will be randomly assigned to one of the two methods and followed for up to 11 years to se…

This study tests whether a special dye called ICG, used with a new imaging device, can help surgeons see how healthy a patient's bone is during surgery. Ten adults with open fractures or bone infections will receive the dye and be imaged. The goal is to see if this technique can …

This early-phase trial tests a fluorescent dye called ABY-029 to help surgeons better see high-grade gliomas (a type of brain tumor) during surgery. About 33 adults with suspected high-grade glioma will receive a small amount of the dye before surgery. The goal is to find the rig…

This study tests a device called the CONVIVO system, which acts like a high-powered microscope during brain tumor surgery. It helps surgeons tell the difference between normal and abnormal tissue right away. About 30 adults with various brain tumors will take part. The goal is to…

This study is testing a device that shines a special light on skin growths to see if they are cancerous or harmless. The device looks for low oxygen levels, which can be a sign of cancer. Researchers will compare the device's results with standard biopsy results in 125 adults who…

This study tests a new way to help breast cancer survivors become more active. Instead of focusing on effort, the program focuses on how exercise makes you feel. About 85 survivors who finished treatment within the last 5 years will join. They will wear an activity monitor and an…

This study tests whether listening to specific music daily can reduce seizure-related brain activity in adults with drug-resistant epilepsy. Participants have an implanted device that records brain activity and will listen to different music types over several months. The goal is…

This pilot study tests whether a trauma-focused therapy (TF-CBT) adapted for autistic youth is practical and well-received in community mental health centers. About 24 autistic children and their therapists will participate. The goal is to see if the therapy is acceptable and fea…

This study tests whether low-dose naltrexone (LDN) can safely reduce pain from diabetic neuropathy, a common complication of diabetes. Thirty-five adults who have not found relief from standard treatments will receive LDN and a placebo in random order. The goal is to see if LDN o…

This study tests whether a special online therapy for insomnia, adapted for people with ulcerative colitis (UC), is helpful and practical. About 20 adults with active UC and insomnia will take part. They will complete online questionnaires, keep a daily sleep diary, and attend 5 …

This study tests whether electronic surveys can help people with advanced cancer report their symptoms and care needs, so their doctors can connect them to palliative (supportive) care services sooner. About 90 adults with incurable solid tumors will participate. The goal is to s…

About half of women stop taking aromatase inhibitors early due to side effects, raising the risk of cancer returning. This study tests whether switching to a different hormone drug or using other symptom-relief methods works better at managing those side effects. Researchers will…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study tests a digital program called I-CARE for teens aged 12-17 who are stuck in the emergency room waiting for a psychiatric hospital bed. The program uses tablet-based videos and workbook exercises to teach coping skills. Researchers want to see if it reduces suicidal tho…

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet virtually with a coach for 8 weekly sessions to learn problem-solving and relaxation skills. The goal is to improve quality of life…

This study is testing an online tool called MyMammogram that helps women ages 39-49 decide whether to get a mammogram. The tool also shares the woman's risk and preferences with her doctor before the visit. The goal is to see if this approach works well in rural healthcare settin…

This study looks at whether giving older adults (65+) with diabetes or high blood pressure access to their visit notes and audio recordings of their appointments helps them feel better and manage their health. About 1,022 participants will be randomly assigned to receive either w…

This study looks at whether a Mediterranean diet can improve gut health in children with cystic fibrosis. Twenty kids aged 3 and older will follow this diet for 6 months. Researchers will check changes in gut bacteria and inflammation markers. The goal is to offer better diet adv…

This study looks at whether adding patients' own goals and concerns to their mental health care plan can help them stay more engaged in treatment. About 2,400 adults with anxiety or depression who are already in collaborative care will use an enhanced questionnaire and dashboard.…

This study looks at how growing up with a heart condition might increase the risk of post-traumatic stress disorder (PTSD). Researchers will survey 1,000 adults with congenital heart disease to find out which experiences—like past surgeries or bullying—are linked to PTSD. They wi…

This pilot study is testing whether active monitoring (regular ultrasounds and check-ups) is as good as or better than immediate biopsy for people with small thyroid nodules that look suspicious on ultrasound. Twenty adults with nodules under 2 cm will be randomly assigned to eit…

This study is testing whether a special nutrition shake given after surgery can help older adults (70+) regain physical and mental function faster. Half of the 100 participants will receive the shake daily for 30 days, while the other half will follow standard recovery advice. Th…

This study looks at ways to encourage homeowners and renters in New Hampshire and Vermont to test their homes for radon, a radioactive gas that can cause lung cancer. In the first phase, participants join focus groups to share their views on radon testing. In the second phase, pa…

This study records brain electrical activity in epilepsy patients who already have electrodes implanted for surgery. Participants perform tasks like viewing pictures, recalling details, and naming objects while their brain signals are measured. The goal is to map where memory, la…

This study explores whether hearing tests, especially in noisy settings, can reveal early signs of mild cognitive impairment (MCI). Researchers will compare 70 adults aged 55–80—some with MCI, some healthy—on how well they hear soft sounds and process speech in noise. The goal is…

This study aims to find out if certain blood markers can predict how well cancer patients respond to immunotherapy. Researchers will collect blood samples from 1500 people with different types of cancer before and during treatment. Participants will be followed for up to 6 months…

This observational study looks at how CFTR modulator therapy affects the nose and sinuses in adults with cystic fibrosis. Researchers will compare bacterial communities, inflammation, sense of smell, and quality of life between patients on the therapy and those not on it. Partici…

This study compares two ways of involving patients, caregivers, clinicians, and community members in research. One method is more consultative, the other more collaborative. Researchers want to see which approach builds more trust and engagement, especially among groups that are …

This study explores whether a test that measures brain waves in response to visual images can be used in a new way for people with hearing loss. Researchers will compare these brain responses to standard hearing tests and thinking skills tests. The goal is to see if this test can…

This study looks at whether a special team of cancer experts, called a Molecular Tumor Board, can help doctors choose better treatments based on the genetic makeup of a patient's tumor. About 192 people with cancer will have their tumor genes analyzed, and the board will suggest …