Dartmouth-hitchcock Medical Center

This study tests whether adding tetrathiomolybdate (TM) to standard capecitabine can lower the chance of breast cancer returning in patients with high-risk triple-negative breast cancer. About 204 participants who have completed initial treatment and surgery will receive either T…

This study tests whether switching between two different chemotherapy combinations can help people with borderline resectable pancreatic cancer. The goal is to shrink the tumor enough for successful surgery and to improve survival without the cancer coming back. About 35 adults w…

This study tests whether certain drug combinations can help people with advanced ER+/HER2- breast cancer whose disease has stopped responding to standard CDK4/6 inhibitor pills. About 135 postmenopausal women will receive one of several treatment arms based on their tumor's genet…

This study tests a new way of giving chemotherapy to people with advanced gastrointestinal cancers, like colorectal or stomach cancer. The approach adjusts the dose of one chemo drug (5-FU) based on how well each patient tolerates the initial dose, aiming to give a stronger, more…

This study tests whether giving e-cigarettes to smokers with mental illness who cannot or do not want to quit smoking can help them switch away from cigarettes and reduce harm. About 250 adults with conditions like schizophrenia, bipolar disorder, or depression who smoke at least…

This study tests if a form of estrogen (estradiol) can help control advanced breast cancer that is hormone-receptor-positive (ER+). It includes 36 post-menopausal women whose cancer has spread or returned and who have already tried other hormone therapies. The goal is to see if w…

This study is testing a laser treatment for cancer that has spread to the spine. The goal is to see if the laser can control tumor growth as well as traditional open surgery, but with fewer risks. About 25 adults with spine tumors will receive the laser procedure and be followed …

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It includes 95 adults whose arm function stopped improving after 1-5 years of rehab. The goal is to see if the surgery can improve arm movement and control.

This study tests a special microscope called CONVIVO that lets surgeons see brain tissue up close during surgery. The goal is to help them tell the difference between normal brain and tumor tissue right away. About 30 adults with different types of brain tumors will take part. Th…

This early-phase trial tests a fluorescent dye called ABY-029 to help surgeons better see high-grade gliomas (a type of brain tumor) during surgery. About 33 adults with suspected high-grade glioma will receive a small amount of the dye before surgery. The goal is to find the rig…

This study is testing a new, non-invasive device that uses a special light to tell the difference between harmless skin growths and non-melanoma skin cancer. About 125 adults with known skin cancer or benign growths will be scanned before their scheduled surgery. The device works…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants (including veterans and civilians) will either start the program right away or wait 3 months. The program involves …

This study is testing whether regular electronic surveys can help people with advanced cancer report their symptoms and care needs, so their doctors can connect them to palliative (supportive) care services more quickly. About 90 adults with incurable solid tumors will participat…

This study looks at whether treating insomnia can improve sleep and possibly reduce pain and inflammation in people with Crohn's disease. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep intervention. The main goal is to see if the treatment …

This study tests a home-based program called HOBSCOTCH-MS for people with multiple sclerosis who have memory or thinking problems. Participants meet weekly with a coach online to learn problem-solving and relaxation skills. The goal is to see if the program improves quality of li…

This study tests a digital program called I-CARE for teens aged 12-17 who are waiting in the emergency room after a suicide attempt or mental health crisis. The program teaches coping skills through a tablet or phone, guided by a non-clinical helper. Researchers want to see if it…

This study tests whether a special music app can reduce seizure-related brain activity in adults with drug-resistant epilepsy who have a brain implant (RNS). Participants will listen to music at home over several months. The goal is to see if this simple, self-administered therap…

This study tests a new way to help breast cancer survivors become more physically active. It compares an exercise plan based on how you feel during activity to a standard plan. About 85 survivors who finished treatment within the last 5 years will wear an activity monitor and ans…

This study tests whether low-dose naltrexone (LDN) can safely reduce pain from diabetic neuropathy, a common complication of diabetes. About 35 adults with painful diabetic neuropathy who haven't found relief from standard treatments will receive LDN and a placebo in random order…

This study looks at two ways to manage side effects from aromatase inhibitors, a hormone therapy for early-stage breast cancer. About half of women stop taking these drugs early due to side effects, raising the risk of cancer returning. The study will compare switching to a diffe…

This study compares two numbing creams for pain during skin procedures like laser and microneedling. One cream is a standard 4% lidocaine, and the other is a stronger mix of three numbing medicines (BLT). About 64 adults will rate their pain on a 0-10 scale to see which cream wor…

This study tests whether a therapy called Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), adapted for autistic youth, works well in community mental health centers. Researchers will enroll 24 autistic children (ages 6-18) and their therapists to see if the therapy is accept…

This study looks at whether a special team of cancer experts, called a Molecular Tumor Board, can help doctors choose better treatments based on the genetic makeup of a patient's tumor. About 192 adults with cancer will have their tumor genes analyzed, and the board will suggest …

This study aims to improve how women in rural areas decide about getting mammograms. Researchers are testing a decision aid called MyMammogram, with or without a summary for their doctor, compared to usual care. About 39 women aged 39-49 and their primary care providers will help…

This study looks at whether a special nutrition shake can help frail older adults recover their strength and thinking abilities after major surgery. Half of the 100 participants will receive the shake daily for 30 days after surgery, while the other half will get standard recover…

This study looks at whether people with Mild Cognitive Impairment (MCI) have trouble hearing in noisy places compared to healthy adults. Researchers will test hearing and thinking skills in 70 volunteers aged 55-80. The goal is to see if simple hearing tests can help detect early…

This study looks at ways to encourage people to test their homes for radon, a radioactive gas that can cause lung cancer. Researchers will test an online tool and reminder messages to see if they help more people request and use free radon test kits. The study involves 172 adults…

This pilot study compares two approaches for managing thyroid nodules that look suspicious on ultrasound: immediate biopsy (usual care) versus active monitoring with regular ultrasounds. The goal is to see which approach leads to less anxiety and better quality of life for patien…

This study is looking at how the brain responds to visual images in people with hearing loss. Researchers will use a test called a Visual Evoked Potential to measure brain waves, focusing on a specific signal called the P300. They will compare these results with standard hearing …

This study observes brain electrical activity in epilepsy patients who already have electrodes implanted for surgery. Participants do simple computer tasks to test memory, language, emotions, and more. The goal is to learn which brain areas control these functions, not to provide…

This observational study looks at how a cystic fibrosis therapy (CFTR modulator) affects the nose and sinuses. Researchers will compare bacteria, inflammation, sense of smell, and quality of life between adults with CF who are on the therapy and those who are not. Participants pr…

This study looks at two ways to check for colon cancer in adults aged 65 to 82 who have had colon polyps before. One group will get a yearly stool test (FIT), and the other will have a colonoscopy. Researchers want to see which method finds advanced growths better over time. Abou…

This study looks at whether adding patients' own goals and concerns to their mental health care plan helps them stay more engaged. About 2,448 adults receiving collaborative care for anxiety or depression will take part. Researchers will compare standard care to an enhanced versi…

This study looks at how living with congenital heart disease from birth may increase the risk of post-traumatic stress disorder (PTSD). Researchers will survey 1,000 adults and interview some to find out which experiences—like past surgeries or bullying—are linked to PTSD. They a…

This study tests a new imaging device that uses a dye called indocyanine green (ICG) to help surgeons see how well bones are getting blood flow during surgery. The goal is to better predict healing and infection risk in patients with severe fractures or bone infections. About 10 …

This study looks at how a Mediterranean diet affects the gut health of children with cystic fibrosis. About 20 kids, ages 3 and older, will follow this diet for 6 months. Researchers will check changes in gut bacteria and inflammation to see if this diet offers better guidance fo…

This study is for people with cancer who are about to start or have already received FDA-approved immunotherapy. Researchers want to see if special blood tests (immune-methylation and cytokine profiling) can predict whether the treatment will work. The goal is to better understan…

This study compares two methods of involving patients, caregivers, clinicians, and community members in research: one where they give advice and another where they work closely with the research team. About 136 adults with experience in pediatric mental health, cancer screening, …