Dartmouth-hitchcock Medical Center

This study tests whether alternating two different chemotherapy combinations before surgery can better shrink borderline pancreatic tumors. The goal is to make more tumors removable by surgery and reduce the chance of cancer returning. About 35 adults with borderline pancreatic c…

This study is testing a minimally invasive laser procedure to control tumors that have spread to the spine. Researchers will observe 25 patients to see if this laser treatment works as well as traditional open surgery at stopping tumor growth. The goal is to see if this less inva…

This study is comparing two methods for monitoring older adults who have had colon polyps in the past. Researchers want to see if an annual at-home stool test works as well as a colonoscopy at finding serious colon problems. The goal is to offer older adults a safer, less invasiv…

This study is testing whether giving estradiol (a form of estrogen) can help control advanced breast cancer that has stopped responding to standard hormone treatments. The trial will enroll 36 post-menopausal women with metastatic breast cancer who have tried at least one prior h…

This study is testing whether adding a copper-lowering drug called tetrathiomolybdate (TM) to standard post-surgery medications can better prevent cancer from spreading or returning in people with high-risk triple-negative breast cancer. It will involve about 204 participants who…

This study is testing whether providing e-cigarettes, with or without counseling support, can help people with mental health conditions who smoke daily reduce the harm from tobacco when they aren't ready to quit completely. It will enroll 250 adults with conditions like depressio…

This study tests whether matching drug combinations to a patient's specific tumor genetics can help control advanced breast cancer that has stopped responding to standard treatments. It will enroll 135 post-menopausal women whose cancer has progressed after initial therapy. Resea…

This study is testing whether a proven trauma therapy can be successfully adapted for autistic youth in real-world community mental health clinics. It will enroll 24 autistic children and teens with trauma symptoms, along with their therapists. The main goal is to see if this mod…

This study is testing a surgical procedure called a 'nerve transfer' to improve arm and hand function in people who have long-term weakness after a stroke. The surgery connects a healthy nerve from the non-paralyzed side of the body to the nerves controlling the weak arm. Researc…

This study is testing a new approach to chemotherapy for advanced gastrointestinal cancers. It aims to see if doctors can safely increase the dose of a key chemo drug for patients who tolerate the standard dose well. The goal is to see if this personalized, higher-dose approach i…

This study is testing a special microscope called the CONVIVO system. It is used during brain tumor surgery to help surgeons see the difference between healthy brain tissue and tumor tissue in real time. The images from the device are compared to standard lab tests from small tis…

This study is testing a new, non-invasive imaging device designed to help doctors tell the difference between harmless skin growths and non-melanoma skin cancers. The device uses a special light to measure oxygen levels in skin tissue, which can indicate cancer. Researchers are e…

This study is testing a special camera system that uses a safe, glowing dye to help surgeons see blood flow and health in damaged bones. It aims to give doctors better information to choose the right treatment for people with severe open fractures or bone infections. The goal is …

This early-stage study is testing the safety of a new fluorescent dye called ABY-029. The goal is to see if the dye can make brain tumors glow under special light during surgery, helping surgeons better distinguish tumor from healthy brain tissue. The study will enroll 33 adults …

This study aims to find the best way to encourage people in New Hampshire and Vermont to test their homes for radon, an invisible gas that is a leading cause of lung cancer. Researchers are testing whether a new online educational program, with or without reminder messages, is mo…

This study is testing whether a daily nutrient shake helps older adults recover their physical strength and thinking skills after major surgery. Half of the 100 participants will receive the shake for one month after leaving the hospital, while the other half will receive standar…

This study is testing whether electronic symptom surveys can help patients with advanced cancer report their needs so doctors can connect them to supportive care services faster. The goal is to see if this approach makes it easier for 90 participants to get help managing symptoms…

This study tests a digital program called I-CARE, designed to help teens who are in a mental health crisis and waiting in emergency rooms for a psychiatric hospital bed. The program uses videos and exercises to teach coping skills during this stressful waiting period. Researchers…

This study is testing a home-based program called HOBSCOTCH-CA, designed to help brain cancer survivors manage memory and thinking problems that often follow their illness. Participants will work one-on-one with a coach over video calls to learn problem-solving and relaxation tec…

This study is testing a home-based video coaching program called HOBSCOTCH-MS. It aims to help people with multiple sclerosis (MS) who are struggling with memory and thinking problems. Participants will work one-on-one with a coach to learn problem-solving and relaxation techniqu…

This study aims to find out which of two prescription numbing creams works better at reducing pain during common cosmetic skin treatments like laser therapy and microneedling. Researchers will compare a standard lidocaine cream to a stronger, compounded cream containing three num…

This study aims to help breast cancer patients stay on their hormone therapy by better managing its side effects. Researchers will compare two approaches for women who develop bothersome symptoms: switching to a different medication versus following standard treatment guidelines.…

This study is testing whether treating insomnia in people with Crohn's disease can improve their sleep and potentially reduce other symptoms like pain and inflammation. Researchers are recruiting 83 participants with both Crohn's disease and insomnia to receive remote treatment. …

This study is testing whether listening to specific music every day can reduce seizure activity and improve mood for adults with hard-to-treat epilepsy. Participants, who already have a special brain implant to monitor seizures, will listen to different music tracks at home for s…

This study is testing whether an exercise program focused on enjoyment helps breast cancer survivors stay more active than traditional exercise programs. Researchers will compare two approaches: one based on how exercise makes you feel versus one based on how hard you work. The s…

This study aims to understand how living with a congenital heart condition affects mental health. Researchers will survey and interview 1,000 adults with congenital heart disease to identify which medical and life experiences increase the risk of developing PTSD. The goal is to l…

This study aims to find out if difficulty hearing speech in noisy places is linked to early, mild changes in memory and thinking. Researchers will compare hearing and cognitive test results between 70 adults with mild memory concerns and healthy adults aged 55-80. The goal is to …

This study aims to find the best way to involve patients, caregivers, and clinicians in health research. Researchers are comparing a traditional 'consultative' approach with a more active 'collaborative' approach across three health topics: pediatric mental health, cancer screeni…

This study is testing a decision aid tool called MyMammogram to help women aged 40-49 in rural areas make informed choices about breast cancer screening. Researchers are working with patients and doctors to refine how the tool is delivered and whether adding doctor communication …

This study aims to see if getting expert advice on a patient's unique tumor genetics helps doctors make better treatment decisions. Researchers will analyze the tumor genes of about 192 cancer patients and have a special panel of experts recommend treatments. They will then track…

This study is testing whether a simple brain wave measurement can help predict how well someone with hearing loss might do with a hearing aid or cochlear implant. Researchers will measure participants' brain responses to visual images and compare them to standard hearing and thin…

This study aims to understand how a specific therapy for cystic fibrosis affects sinus health. Researchers will compare adults with CF who are on the therapy to those who are not, tracking bacteria, inflammation, sense of smell, and quality of life over two years. Participants wi…

This study aims to identify blood markers that can predict whether cancer patients will respond to FDA-approved immunotherapy treatments. Researchers will follow 1,500 patients receiving treatments like pembrolizumab or nivolumab, tracking their response over six months. The goal…

This study aims to understand how different parts of the human brain work by recording its electrical activity. It enrolls people with epilepsy who already have electrodes implanted for their medical care, as well as healthy volunteers. Participants complete simple computer tasks…