Could a Low-Dose opioid blocker ease diabetic nerve pain without the risks?
NCT ID NCT04678895
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether low-dose naltrexone (LDN) can safely reduce pain from diabetic neuropathy, a common complication of diabetes. Thirty-five adults who have not found relief from standard treatments will receive LDN and a placebo in random order. The goal is to see if LDN offers a non-opioid alternative for managing this chronic pain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low-dose naltrexone (LDN)
- What this could lead to
- If it works, this could offer a safe, non-opioid pain relief option for people with painful diabetic neuropathy.
- What could go wrong
- This is a small, early-phase trial with only 35 participants. It may not show a clear benefit, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dartmouth-Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03766, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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