Stool test vs. colonoscopy: which is better for older adults with polyps?

NCT ID NCT05612347

Recruiting now Diagnosis Sponsor: Dartmouth-Hitchcock Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This study compares two ways to monitor older adults (ages 65-82) who have had colon polyps in the past: an annual stool test (FIT) or a colonoscopy every few years. About 9,000 participants will be randomly assigned to one of the two methods and followed for up to 11 years to see which approach detects advanced polyps or cancer better. The goal is to find the most effective and convenient screening option for this age group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could show that a simple annual stool test is as effective as colonoscopy for monitoring older adults with a history of polyps, potentially reducing the need for invasive procedures.
What could go wrong: This is a comparative effectiveness study, not a test of a new treatment. Results may show that stool testing misses some advanced polyps, and the findings may not apply to people with higher-risk conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal adenoma colorectal neoplasm Digestive System Diseases digestive system disorder polyp of large intestine colorectal cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL ADENOMA COLORECTAL CANCER COLORECTAL NEOPLASMS COLORECTAL POLYP DIGESTIVE SYSTEM DISEASE

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Dartmouth Health
RECRUITING

Lebanon, New Hampshire, 03756, United States

Contact Email: •••••@•••••
Henry Ford
RECRUITING

Detroit, Michigan, 48202, United States
Intermountain Health
RECRUITING

Sandy City, Utah, 84094, United States
James A. Haley Veterans Hospital
RECRUITING

Tampa, Florida, 33612-4745, United States
Jennifer Moreno Department of Veterans Affairs Medical Cneter
RECRUITING

San Diego, California, 92161, United States
Kaiser Permanente Northern California
RECRUITING

Walnut Creek, California, 94596, United States

Contact Email: •••••@•••••
Kaiser Permanente Northwest
ACTIVE_NOT_RECRUITING

Portand, Oregon, 97232, United States
London Health Sciences Centre Research Institute
RECRUITING

London, Ontario, N6A 5W9, Canada
MedStar Health
RECRUITING

Washington D.C., District of Columbia, 20010, United States
New York Harbor Health Care System - Dept of Veterans Affairs
RECRUITING

New York, New York, 10010, United States
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Oregon Health & Science University (Knight Cancer Institute)
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Richard L. Roudebush VA Medical Center
RECRUITING

Indianapolis, Indiana, 46202, United States
University of Alabama Birmingham
ACTIVE_NOT_RECRUITING

Birmingham, Alabama, 35233, United States
University of Arizona
RECRUITING

Tucson, Arizona, 85719, United States
University of British Columbia
RECRUITING

Vancouver, British Columbia, V6Z 1Y6, Canada
University of Calgary
RECRUITING

Calgary, Alberta, T2N 5A1, Canada
University of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
University of Manitoba
RECRUITING

Winnipeg, Manitoba, R3EOW3, Canada
University of Michigan Health
RECRUITING

Ann Arbor, Michigan, 48105, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
University of Virginia Health
RECRUITING

Charlottesville, Virginia, 22903, United States

Contact Email: •••••@•••••
Wake Forest University Health Sciences
RECRUITING

Charlotte, North Carolina, 28204, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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