Stool test vs. colonoscopy: which is better for older adults with polyps?
NCT ID NCT05612347
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways to monitor older adults (ages 65-82) who have had colon polyps in the past: an annual stool test (FIT) or a colonoscopy every few years. About 9,000 participants will be randomly assigned to one of the two methods and followed for up to 11 years to see which approach detects advanced polyps or cancer better. The goal is to find the most effective and convenient screening option for this age group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could show that a simple annual stool test is as effective as colonoscopy for monitoring older adults with a history of polyps, potentially reducing the need for invasive procedures.
What could go wrong
This is a comparative effectiveness study, not a test of a new treatment. Results may show that stool testing misses some advanced polyps, and the findings may not apply to people with higher-risk conditions.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Dartmouth Health
RECRUITINGLebanon, New Hampshire, 03756, United States
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Henry Ford
RECRUITINGDetroit, Michigan, 48202, United States
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Intermountain Health
RECRUITINGSandy City, Utah, 84094, United States
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James A. Haley Veterans Hospital
RECRUITINGTampa, Florida, 33612-4745, United States
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Jennifer Moreno Department of Veterans Affairs Medical Cneter
RECRUITINGSan Diego, California, 92161, United States
Contact
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Kaiser Permanente Northern California
RECRUITINGWalnut Creek, California, 94596, United States
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Kaiser Permanente Northwest
ACTIVE_NOT_RECRUITINGPortand, Oregon, 97232, United States
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London Health Sciences Centre Research Institute
RECRUITINGLondon, Ontario, N6A 5W9, Canada
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MedStar Health
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact
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New York Harbor Health Care System - Dept of Veterans Affairs
RECRUITINGNew York, New York, 10010, United States
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Northwestern Memorial Hospital
RECRUITINGChicago, Illinois, 60611, United States
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Oregon Health & Science University (Knight Cancer Institute)
RECRUITINGPortland, Oregon, 97239, United States
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Richard L. Roudebush VA Medical Center
RECRUITINGIndianapolis, Indiana, 46202, United States
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University of Alabama Birmingham
ACTIVE_NOT_RECRUITINGBirmingham, Alabama, 35233, United States
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University of Arizona
RECRUITINGTucson, Arizona, 85719, United States
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University of British Columbia
RECRUITINGVancouver, British Columbia, V6Z 1Y6, Canada
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University of Calgary
RECRUITINGCalgary, Alberta, T2N 5A1, Canada
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University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
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University of Manitoba
RECRUITINGWinnipeg, Manitoba, R3EOW3, Canada
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University of Michigan Health
RECRUITINGAnn Arbor, Michigan, 48105, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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University of Virginia Health
RECRUITINGCharlottesville, Virginia, 22903, United States
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