Could watching and waiting beat the needle for thyroid nodules?
NCT ID NCT06220656
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study is testing whether active monitoring (regular ultrasounds and check-ups) is as good as or better than immediate biopsy for people with small thyroid nodules that look suspicious on ultrasound. Twenty adults with nodules under 2 cm will be randomly assigned to either immediate biopsy or active monitoring. The main goal is to compare anxiety levels and thyroid-related quality of life after 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could show that active monitoring is a safe and less anxiety-provoking option for some thyroid nodules, potentially reducing unnecessary biopsies.
What could go wrong
This is a very small pilot study with only 20 participants, so results may not apply to everyone. It is designed to test feasibility, not to prove which approach is better.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Dartmouth Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••