Nodular goiter

This study is testing a new procedure called nanosecond pulsed field ablation (nsPFA) to treat benign (non-cancerous) thyroid nodules. The goal is to see if this non-surgical treatment can shrink the nodules and improve patients' quality of life. The study will enroll 30 adults w…

This study tests a new device that uses electrical pulses to shrink benign (non-cancerous) thyroid nodules. About 100 adults with symptomatic nodules will receive the treatment and be followed to see if the nodule shrinks and symptoms improve. The goal is to offer a less invasive…

This study tests whether Prunella oral liquid, a herbal remedy, can safely shrink benign (non-cancerous) thyroid nodules. About 234 adults with solid nodules between 1 and 3 cm will take the liquid or a placebo for 9 months. Researchers will measure changes in nodule size and che…

This study is for people with small thyroid nodules (under 2 cm) that might be cancerous. Instead of immediate surgery, which can lead to lifelong thyroid medication and other side effects, researchers want to see if regular check-ups and ultrasounds are a safe option. They will …

This pilot study will test the safety of thyroid artery embolization (TAE) in 10 UK patients with benign thyroid nodules or goitre. TAE is a minimally invasive procedure that blocks blood flow to the thyroid gland using tiny particles, causing it to shrink. The goal is to see if …

This study tests whether a device called PTeye, which uses near-infrared light to make parathyroid glands glow, helps surgeons find and protect these tiny glands during thyroid surgery. The trial will compare outcomes in 154 patients who have their first total thyroidectomy, with…

This study looks at a new DNA-based test to find thyroid cancer in people with thyroid nodules. Researchers want to see if this test can accurately tell if a nodule is cancer or not, which could help avoid unnecessary surgeries. About 22 adults with thyroid nodules will provide s…

This study aims to develop an AI model that combines ultrasound images and cell slide images to more accurately predict cancer risk in thyroid nodules that have uncertain results from a needle biopsy. About 396 patients with these uncertain results will be included. The goal is t…

This study tests whether adding contrast-enhanced ultrasound to standard ultrasound can improve the diagnosis of thyroid cancer. Researchers are comparing two scoring methods in 800 participants with thyroid nodules. The goal is to see which method better identifies cancer and re…

This study is testing whether a blood test can diagnose thyroid cancer as accurately as a traditional biopsy. Researchers will analyze tiny particles called extracellular vesicles from blood and tissue samples of 250 adults with thyroid nodules or cancer. The goal is to find a le…

This study tests whether using a special dye (indocyanine green) during total thyroidectomy helps surgeons see and protect the parathyroid glands, reducing the risk of permanent hypoparathyroidism. About 242 adults scheduled for total thyroid removal will be randomly assigned to …

This study is testing whether giving patients unlimited access to a secure website with an explanatory video about thyroid surgery can lower their anxiety before the operation. About 220 adults scheduled for thyroid surgery will take part. Researchers will measure anxiety using s…

This study tests whether adding neck massage, stretches, and pain education to standard voice exercises can improve voice, swallowing, and scar quality after total thyroidectomy. Adults scheduled for total thyroid removal are invited to participate. They will attend sessions with…

This study tests whether giving a drug called dexmedetomidine during thyroid surgery helps patients wake up more smoothly. The drug aims to reduce coughing, agitation, and the amount of anesthesia needed. About 100 adults having thyroid surgery will be randomly assigned to receiv…

This study tests whether a cold plasma device applied during and after thyroid surgery can speed up wound healing and reduce pain and infection. About 26 adults having their thyroid removed will be randomly assigned to get either standard wound care or the plasma treatment. Resea…

This study is testing a procedure called thyroid artery embolization (TAE) for people with large thyroid nodules that press on the throat or windpipe, causing symptoms like trouble swallowing or breathing. The procedure blocks blood flow to the nodules to shrink them. Researchers…

This study tests whether smelling lavender essential oil during awake ear, nose, and throat procedures can lower anxiety and pain. About 184 adults will be randomly assigned to receive either lavender aromatherapy or a placebo (odorless liquid). Participants will rate their anxie…

This study is testing a minimally invasive procedure called radiofrequency ablation (RFA) to treat benign thyroid nodules that cause symptoms like discomfort or cosmetic issues. It focuses on LatinX patients who want to avoid surgery. The goal is to see if RFA can safely shrink t…

This study tests a decision support tool that uses blood samples from the first two weeks after thyroid surgery to predict the best levothyroxine dose. Normally, dose adjustments take months of trial and error. The trial will enroll 240 patients and compare the tool's guidance to…

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study reviews 10 years of medical records from 600 adults who had thyroid surgery at Minia University Hospital. The goal is to find out which patients are most likely to develop low calcium levels after surgery, a common complication. By identifying key risk factors, doctors…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study looks at two treatments for non-cancerous thyroid nodules: surgery and radiofrequency ablation. Researchers will track how much the nodules shrink, changes in thyroid hormone levels, and quality of life. About 100 adults with benign nodules will participate, and the go…

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study aims to improve a prediction model that helps doctors know how difficult a less invasive thyroid surgery might be. Researchers will observe 300 people with thyroid cancer or benign nodules to see which factors, like age, weight, and tumor size, affect surgery difficult…

This study aims to create and test a scoring system called RTAS to evaluate how well surgeons perform robotic thyroidectomy, a surgery to remove all or part of the thyroid gland. Researchers will observe 200 participants with thyroid cancer or benign nodules who are having this s…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This pilot study is testing whether active monitoring (regular ultrasounds and check-ups) is as good as or better than immediate biopsy for people with small thyroid nodules that look suspicious on ultrasound. Twenty adults with nodules under 2 cm will be randomly assigned to eit…

This study looks at how well ultrasound-guided heat ablation works for non-cancerous thyroid nodules and aims to create an AI model that can predict treatment results. Researchers will follow 1500 adults who choose this minimally invasive procedure instead of surgery. The goal is…

This study looks at the best dose of a sedative called ciprofol for people having thyroid surgery. About 101 adults will receive this medicine to put them to sleep, and researchers will track how their brain activity changes. The goal is to find the exact amount needed for safe a…

This study aims to create a reliable questionnaire to measure swallowing and throat discomfort in people with goiter or after thyroid removal (thyroidectomy). Researchers will interview patients to develop the questions, then test the questionnaire before and after surgery. The s…

This study is testing whether a special type of ultrasound called multiparametric ultrasound (mpUS) can provide more detailed images of tissue than standard ultrasound. Researchers will compare mpUS results with regular tests in up to 85 people who are at high risk for pancreatic…

This study looks at the tiny blood vessels inside thyroid nodules using a special ultrasound technique. Researchers hope this will help doctors better tell which nodules are harmless and which might need surgery. The study involves 50 adults, including patients with thyroid nodul…

This study tests a decision aid for people with small thyroid nodules or early thyroid cancer. Participants get extra information to help them choose a treatment that matches their values. They fill out surveys about their satisfaction and decision-making process. The goal is to …

This study follows 180 people who had a benign thyroid nodule treated with radiofrequency heat ablation three years ago. Researchers will use ultrasound and a fine-needle biopsy to see how the nodule looks and whether any cells have changed. The goal is to create a better way to …