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10-Year study aims to predict dangerous calcium drop after thyroid removal

NCT ID NCT07428057

Knowledge-focused Sponsor: Minia University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
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Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
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Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 4 times

Summary

This study reviews 10 years of medical records from 600 adults who had thyroid surgery at Minia University Hospital. The goal is to find out which patients are most likely to develop low calcium levels after surgery, a common complication. By identifying key risk factors, doctors hope to better prepare and manage patients in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This retrospective cohort study will include adult patients (aged 18 years and older) who underwent a thyroidectomy procedure at Minia University Hospital, a tertiary care centre in Egypt, between January 1, 2014, and December 31, 2024. The target population consists of approximately 600 consecutive patients who meet the eligibility criteria. This includes patients with available medical records containing complete surgical and postoperative data, documented postoperative serum calcium levels, and a minimum of 6 months of follow-up or a documented outcome status. Patients will be excluded if they have preoperative hypocalcemia, pre-existing parathyroid disorders, chronic kidney disease (Stage 3 or higher), or other conditions that significantly affect calcium metabolism. The study population represents a consecutive sample of all patients meeting these criteria over the 10-year study period at this single academic center.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 years or older at time of surgery * Underwent thyroidectomy at Minia University Hospital * Availability of medical records with complete surgical and postoperative data * Documented serum calcium levels measured postoperatively * Minimum follow-up of 6 months postoperatively or documented outcome status Exclusion Criteria: * Age less than 18 years at time of surgery * Preoperative hypocalcemia (serum calcium \<8.0 mg/dL or ionized calcium \<1.0 mmol/L) * Pre-existing parathyroid disorders (primary hyperparathyroidism, hypoparathyroidism, secondary or tertiary hyperparathyroidism) * Chronic kidney disease Stage 3 or higher (estimated glomerular filtration rate \<60 mL/min/1.73m²) * Malabsorption syndromes affecting calcium metabolism (celiac disease, inflammatory bowel disease,short bowel syndrome) * Concurrent planned parathyroidectomy * History of neck irradiation * Chronic use of medications significantly affecting calcium metabolism (bisphosphonates, denosumab,cinacalcet, chronic corticosteroids) * Incomplete medical records lacking essential data including surgical details, postoperative calcium levels,or follow-up data * Patients lost to follow-up before 6-month endpoint without documented outcome status

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Conditions

The condition(s) this trial relates to.

autosomal dominant hypocalcemia Hypocalcemia hypoparathyroidism nodular goiter Postoperative Complications thyroid cancer thyroid gland disorder Thyroid Neoplasms Thyroid Nodule

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypocalcemia Postoperative complications Thyroid cancer Thyroid dysfunction Thyroid nodule

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Minia University Hospital

    RECRUITING

    Minya, Minya Governorate, 61519, Egypt

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