Hypoparathyroidism

This phase 2 trial tests whether ruxolitinib, a drug already approved for certain blood disorders, can help regrow hair in people with APECED, a rare immune condition that often causes severe alopecia areata. About 70 participants aged 12 to 75 will take the pill twice daily for …

This early-phase trial tests an mRNA drug called XH02 in 6 adults with hypoparathyroidism, a condition where the body lacks parathyroid hormone (PTH). The drug is designed to instruct cells to produce PTH after being given through a vein. The main goal is to check safety, while a…

This study tests an mRNA drug called XH-02 that helps the body produce parathyroid hormone (PTH) in adults with hypoparathyroidism, a condition where PTH levels are too low. The drug is given as a shot under the skin. The goal is to see if it safely improves calcium and phosphoru…

This study looks at whether taking a lower dose of calcium (twice a day) works as well as a higher dose (four times a day) to prevent low calcium symptoms in the two weeks after thyroid surgery. About 50 adults who develop mild low calcium after surgery will be split into two gro…

This phase 3 trial tests higher daily doses (over 30 mcg) of palopegteriparatide (Yorvipath) in 36 adults with chronic hypoparathyroidism. Participants already on the drug will have their dose adjusted to find the best level for controlling calcium without needing extra vitamin D…

This study tests a drug called encaleret in 28 children (birth to 17 years) with autosomal dominant hypocalcemia type 1 (ADH1), a rare genetic condition causing low blood calcium. The goal is to see if the drug can safely raise calcium levels and reduce urinary calcium loss. Part…

This study tests a simple injection of mashed parathyroid tissue into the forearm during thyroid surgery. The goal is to prevent permanent low calcium levels that require lifelong medication. About 100 adults having thyroid surgery will receive this injection, and researchers wil…

This early-stage trial tests an mRNA drug called XH-02 in 15 adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone. The drug is injected under the skin to help replace the missing hormone and control calcium levels. The main goal is to…

This early-phase study tests whether transplanting donated parathyroid tissue into the forearm can help people with hypoparathyroidism achieve normal calcium and phosphorus levels. The trial enrolls 3 adults who have low parathyroid hormone after surgery. Participants will receiv…

This study tests a device called PTeye™ that uses near-infrared light to help surgeons see and protect tiny parathyroid glands during total thyroid removal. About 210 adults in Hong Kong will be randomly assigned to standard surgery or PTeye™-assisted surgery. The goal is to see …

This phase 2 trial tests a drug called emapalumab in 10 people with APECED, a rare disease where the immune system attacks the body. The drug aims to reduce gut inflammation (enteritis) that causes severe symptoms. Participants receive 7 IV doses over 6 months, and researchers tr…

This study tests whether using a special camera (autofluorescence imaging) during thyroid cancer surgery can lower the risk of hypoparathyroidism, a condition where the parathyroid glands stop working properly. About 160 adults having their thyroid removed will be randomly assign…

This study tests a new form of calcium called AMOR-1 in 81 adults with hypoparathyroidism, a condition where the body can't control calcium levels. Participants will take either AMOR-1 or standard calcium pills to see if AMOR-1 can better maintain normal calcium levels while allo…

This study tests whether a device called PTeye, which uses near-infrared light to make parathyroid glands glow, helps surgeons find and protect these tiny glands during thyroid surgery. The trial will compare outcomes in 154 patients who have their first total thyroidectomy, with…

This study tests whether measuring parathyroid hormone (PTH) soon after thyroid removal can prevent symptomatic hypoparathyroidism, a condition causing low calcium and uncomfortable symptoms. About 336 adults having thyroid surgery will be monitored. If early PTH testing works, i…

This study tests whether using a special dye (indocyanine green) during total thyroidectomy helps surgeons see and protect the parathyroid glands, reducing the risk of permanent hypoparathyroidism. About 242 adults scheduled for total thyroid removal will be randomly assigned to …

This study reviews 10 years of medical records from 600 adults who had thyroid surgery at Minia University Hospital. The goal is to find out which patients are most likely to develop low calcium levels after surgery, a common complication. By identifying key risk factors, doctors…

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…

This study enrolls up to 15,000 children with known or suspected endocrine or metabolic disorders, along with their family members. Researchers will collect medical records, blood, saliva, and other samples to identify genetic changes linked to these conditions. The goal is to be…

This study follows up to 3,000 people who have, are at risk for, or are related to someone with a parathyroid disorder. Researchers will collect medical records, questionnaires, and samples like blood and saliva to learn what causes these conditions and how they change over time.…

This study aims to understand why some people get severe or unusual fungal infections due to immune system problems. Researchers will collect blood, tissue, and other samples from up to 1,200 participants over 25 years. No new treatments are being tested; the goal is to learn mor…

This study follows 300 adults in Estonia who have their entire thyroid gland removed. The goal is to find out who is most likely to develop hypoparathyroidism—a condition where calcium levels drop after surgery—and whether low magnesium plays a role. Participants answer a questio…

This study enrolls adults with known or suspected endocrine (hormone gland) disorders, such as diabetes or thyroid disease, to help researchers learn more about these conditions. Participants will undergo medical exams, blood and imaging tests, and possibly genetic testing. The m…

This study is not testing a new drug or treatment. Instead, researchers want to make sure their lab tests and equipment give accurate and repeatable results when studying conditions like obesity, diabetes, heart disease, and bone loss. Up to 100 healthy volunteers and people with…

This study looks at how much of the drug palopegteriparatide (YORVIPATH) gets into breast milk. It involves 10 women with hypoparathyroidism who are already taking the drug and breastfeeding. Researchers will collect milk samples to measure drug levels, helping understand safety …

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This registry study is collecting data from 50 women aged 15–50 who took YORVIPATH (palopegteriparatide) for hypoparathyroidism around the time of pregnancy or while breastfeeding. Researchers will monitor pregnancy complications, birth outcomes, and infant health through the fir…

This observational study will follow 2000 children and adults with imprinting disorders—rare genetic conditions like Silver-Russell and Prader-Willi syndromes. Researchers aim to describe the natural history of these diseases and identify common metabolic profiles, risks for obes…

This study follows 106 adults with hypoparathyroidism for three years to see how the disease affects organs like the kidneys and brain. Researchers will measure kidney function and look for calcium buildup in the kidneys and brain using optional CT scans. The goal is to better un…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…