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New hope for kids with rare calcium disease: encaleret trial launches

NCT ID NCT07080385

Recruiting now Disease control Sponsor: Calcilytix Therapeutics, Inc., a BridgeBio company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a drug called encaleret in 28 children (birth to 17 years) with autosomal dominant hypocalcemia type 1 (ADH1), a rare genetic condition causing low blood calcium. The goal is to see if the drug can safely raise calcium levels and reduce urinary calcium loss. Participants will take oral tablets and be monitored for several months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
encaleret (oral tablet)
What this could lead to
If successful, this could provide a targeted treatment to help children with ADH1 maintain normal calcium levels and reduce symptoms.
What could go wrong
This is an early-to-mid-stage trial with only 28 participants, so results may not apply to all. Side effects and long-term safety are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant hypocalcemia 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOSOMAL DOMINANT HYPOCALCEMIA TYPE 1 (ADH1)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Children's National Medical Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Nemours Children's Health

    RECRUITING

    Jacksonville, Florida, 32207, United States

  • Royal London Hospital

    RECRUITING

    London, E1 1FR, United Kingdom

  • Royal Manchester Children's Hospital

    RECRUITING

    Manchester, M13 9WL, United Kingdom

  • The Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06511, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.