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Hypoparathyroidism
MONDO:0001220Hypoparathyroidism is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms include abdominal pain, brittle nails, cataracts, dry hair and skin, muscle cramps, tetany, pain in the face, legs, and feet, seizures, tingling sensation, and weakened tooth enamel (in children). It may be caused by injury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism, metabolic alkalosis, DiGeorge syndrome, and type I polyglandular autoimmune syndrome. The goal of treatment is to restore the calcium and mineral balance in the body.
Also known as: hypoparathyroidism, idiopathic (subtype), parathyroid, underactivity of
65 clinical trials for this condition and its sub-types.
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Glowing goggles could prevent calcium crash after thyroid surgery
Disease control Not yet recruitingThis study tests whether a wearable goggle system that makes parathyroid glands glow can help surgeons find and protect them during thyroid removal. About 280 adults having thyroid surgery will take part. The goal is to reduce the risk of low calcium levels after surgery, a commo…
Phase: NA • Sponsor: Ss. Cyril and Methodius University of Skopje • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Single-Patient trial aims to tackle obesity in rare bone disorder
Disease control Not yet recruitingThis phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Greek study aims to better measure Hypoparathyroidism's impact
Knowledge-focused Not yet recruitingThis study will translate and test two questionnaires (HPES-Symptom and HPES-Impact) for Greek-speaking adults with chronic hypoparathyroidism. Researchers will enroll 200 patients across several hospitals in Greece. The goal is to ensure the questionnaires accurately capture pat…
Sponsor: Aristotle University Of Thessaloniki • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:55 UTC