New study aims to decode cancer risk in treated thyroid nodules

NCT ID NCT05726981

Recruiting now Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study follows 180 people who had a benign thyroid nodule treated with radiofrequency heat ablation three years ago. Researchers will use ultrasound and a fine-needle biopsy to see how the nodule looks and whether any cells have changed. The goal is to create a better way to spot cancer in these treated nodules, since current ultrasound rules don't apply well after ablation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiofrequency thermal ablation
What this could lead to: If successful, this could create a new ultrasound-based system to better predict cancer risk in treated thyroid nodules, reducing unnecessary biopsies.
What could go wrong: This is an early exploratory study with no control group, so results may not apply to all patients. The findings are descriptive and may not change current practice.

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Conditions

The condition(s) this trial relates to.

benign thyroid gland neoplasm nodular goiter Thyroid Nodule

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FINE NEEDLE ASPIRATION BIOPSY THERMAL ABLATION THYROID NODULES

Contacts and locations

Locations

Hospital Pitié-Salpêtrière - Department of Thyroid and Endocrine Tumour Pathologies
RECRUITING

Paris, 75651, France

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