Nodular goiter
MONDO:0006869Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.
Also known as: goiter, nodular, nodular goiter, nodular goiter (disease), nodular goitre (disease), nodular goitre NOS
43 clinical trials for this condition and its sub-types.
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Broader categories
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AI boosts thyroid nodule diagnosis, may cut unnecessary biopsies
Diagnosis CompletedThis study tested whether artificial intelligence (AI) can improve the accuracy of contrast-enhanced ultrasound for diagnosing thyroid nodules. Nearly 2,000 participants had both an ultrasound and a biopsy to confirm their diagnosis. Researchers compared how well doctors could id…
Phase: NA • Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University • Aim: Diagnosis
Last updated Jun 27, 2026 12:00 UTC
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Thinner needle for thyroid biopsy may reduce pain without sacrificing accuracy
Symptom relief CompletedThis study compares two needle sizes (21-gauge vs 27-gauge) used for ultrasound-guided fine needle biopsy of thyroid nodules. The goal is to see which size causes less pain and discomfort during the procedure while still collecting enough cells for diagnosis. Adults with thyroid …
Phase: NA • Sponsor: Izmir Ataturk Training and Research Hospital • Aim: Symptom relief
Last updated Aug 01, 2026 00:00 UTC
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No-Drain thyroid surgery shows promise for benign nodules
Symptom relief CompletedThis study looked at whether removing benign thyroid nodules without placing a surgical drain is safe and effective. Eighty adults having thyroid surgery were randomly assigned to either the standard drain or a no-drain, sutureless technique. The goal was to see if the no-drain a…
Phase: NA • Sponsor: Minia University • Aim: Symptom relief
Last updated Jun 27, 2026 13:02 UTC
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Tiny scope, big difference? study tests Microscope-Assisted thyroid surgery
Symptom relief CompletedThis study compared two types of thyroid surgery: one using a microscope and the standard approach. Researchers looked at blood loss, nerve damage, and low calcium levels after surgery in 74 patients with thyroid cancer or other thyroid conditions. The goal was to see if the micr…
Phase: NA • Sponsor: Shahida Islam Medical Complex • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Neck exercises after thyroid surgery show promise for faster recovery
Symptom relief CompletedThis study tested whether doing gentle neck exercises for 10 days after thyroid surgery could reduce pain and improve quality of life. 93 adults who had their thyroid removed were split into two groups: one did the exercises, the other received standard care. Researchers measured…
Phase: NA • Sponsor: Istanbul University - Cerrahpasa • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Blue spray may shield nerves during thyroid surgery
Symptom relief CompletedThis study tested whether spraying a blue dye called methylene blue onto tissues during thyroid surgery helps surgeons better see and protect the nerve that controls voice and the glands that regulate calcium. 136 adults with benign thyroid nodules took part. The goal was to redu…
Phase: NA • Sponsor: Services Hospital, Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 09:03 UTC
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Skipping thyroid ultrasound after PET may be safe, study suggests
Knowledge-focused CompletedThis study examines whether patients who have a thyroid nodule found on a PET scan can safely skip a follow-up ultrasound without affecting their survival. Researchers will compare death rates over 7 years between those who had an ultrasound within 3 months and those who did not.…
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Aug 12, 2026 00:00 UTC
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Simple blood test during thyroid surgery may predict dangerous calcium drop
Knowledge-focused CompletedThis study investigates whether measuring ionized calcium levels before, during, and after total thyroidectomy can predict which patients will develop low calcium levels (hypocalcemia) after surgery. Researchers will track calcium and parathyroid hormone levels in 327 adults unde…
Sponsor: Emrecan Deniz • Aim: Knowledge-focused
Last updated Jul 16, 2026 00:00 UTC
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Can a simple conversation tool reduce unnecessary thyroid biopsies?
Knowledge-focused CompletedThis study tested a digital conversation aid to help patients and doctors make shared decisions about thyroid biopsy. Researchers enrolled 107 adults with thyroid nodules to see if using the tool during clinic visits was practical. The goal was to gather information for planning …
Phase: NA • Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC