THYROID NEOPLASMS

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.

This study tests a therapy called EMDR (eye movement desensitization and reprocessing) to see if it can reduce post-traumatic stress and emotional distress in people with advanced thyroid cancer. About 25 participants will receive both group and individual EMDR sessions. The goal…

This study tests a website designed to help thyroid cancer patients manage symptoms after radioactive iodine (RAI) treatment. About 88 adults who have had RAI in the past three years will either use this special website or a standard information site for four weeks. Researchers w…

This study is looking at how well treatment given before surgery works for people with advanced thyroid cancer. Researchers will measure tumor shrinkage using scans and lab tests, and track how patients do over time. About 120 participants will be observed to see if this approach…

This study aims to collect tumor and healthy tissue samples from up to 2,415 people scheduled for surgery or biopsy for endocrine tumors (such as thyroid, adrenal, or pancreatic tumors). Researchers will analyze the samples to find genetic and other molecular differences that cou…

This study aims to find the genes that cause pheochromocytoma and paraganglioma, rare tumors of the nervous system. Researchers will analyze DNA from up to 2,000 patients and their family members to link specific genetic changes to tumor development. The goal is to improve geneti…

This pilot study compares two approaches for managing thyroid nodules that look suspicious on ultrasound: immediate biopsy (usual care) versus active monitoring with regular ultrasounds. The goal is to see which approach leads to less anxiety and better quality of life for patien…