Could Pre-Surgery drugs shrink thyroid tumors and improve outcomes?
NCT ID NCT07419932
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether giving targeted drugs before surgery can shrink tumors in people with locally advanced thyroid cancer. About 120 participants will receive one of several drug combinations based on their tumor's genetic profile. The goal is to see if this approach makes surgery easier and improves long-term results.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Multitarget Tyrosine Kinase Inhibitors (lenvatinib, anlotinib), BRAF inhibitor dabrafenib and MEK inhibitor trametinib, RET Inhibitor (selpercatinib, pralsetinib)
- What this could lead to
- If successful, this could show that giving targeted drugs before surgery helps shrink advanced thyroid tumors, potentially leading to less extensive surgery and better long-term control.
- What could go wrong
- This is an early observational study, not a randomized trial, so results may not prove effectiveness. Side effects from the drugs could be serious, and not all patients may respond.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fujian Medical University Union Hospital
RECRUITINGFuzhou, Fujian, 350001, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new oral drug outsmart Radioiodine-Resistant thyroid cancer?
- Can an immune booster make radioiodine more effective against thyroid cancer?
- Hidden thyroid cancers may be more common in Graves' disease than thought
- Can math make thyroid hormone therapy more precise?
- Can AI help surgeons see thyroid cancer more clearly?