THYROID NEOPLASMS

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This study is testing whether giving targeted drugs before surgery can shrink tumors in people with locally advanced thyroid cancer. About 120 participants will receive one of several drug combinations based on their tumor's genetic profile. The goal is to see if this approach ma…

This pilot study is testing whether a therapy called EMDR (eye movement desensitization and reprocessing) can help reduce post-traumatic stress and psychological distress in people with advanced thyroid cancer. The study will enroll 25 participants who have cancer and PTSD sympto…

This study tests a website designed to help thyroid cancer patients manage symptoms after radioactive iodine (RAI) treatment. About 88 adults who had RAI in the last three years will use either the new website or a standard one for four weeks. Researchers will check if the tool i…

This study enrolls people with endocrine tumors (such as thyroid, parathyroid, adrenal, or pancreatic tumors) who are scheduled for surgery or biopsy. Researchers collect samples of the tumor, nearby healthy tissue, blood, and urine to analyze genetic and molecular changes. The g…

This pilot study is testing whether active monitoring (regular ultrasounds and check-ups) is as good as or better than immediate biopsy for people with small thyroid nodules that look suspicious on ultrasound. Twenty adults with nodules under 2 cm will be randomly assigned to eit…

This study looks at the genes of people with rare nervous system tumors called pheochromocytoma and paraganglioma. Researchers want to find the genetic changes that cause these tumors and how they affect health. Up to 2,000 patients and their family members will provide DNA sampl…