Dartmouth-hitchcock Medical Center

This study tests the drug letrozole in postmenopausal women with early-stage ER+ breast cancer. Participants take letrozole for 4 to 24 weeks before surgery to see how the tumor changes and to check if they take the medication as prescribed. The goal is to improve treatment for t…

This Phase 3 trial tested a stem cell transplant using blood stem cells from a half-matched (haploidentical) donor in 21 people with various blood cancers. The goal was to see if this approach could help patients who don't have a fully matched donor. Participants received chemoth…

This study tests a program called I-CARE for teens aged 12-17 who are in a medical hospital waiting for mental health treatment after a suicide-related emergency. The program uses 7 short videos and workbook activities to help lower emotional distress and suicidal thoughts. Resea…

This study looks at whether treating insomnia can help people with Crohn's disease feel better, including reducing pain and inflammation. About 83 adults with mild to moderate Crohn's and insomnia will receive a remote sleep treatment. The main goal is to see if the approach is p…

This pilot study tests a new group program called Move Healthier, designed to help people with overweight or obesity increase their exercise using cognitive and behavioral skills. The goal is to see if it boosts physical activity without raising the risk of disordered eating. Onl…

This study looked at how satisfied patients are with two ways of managing difficulty urinating after gynecologic surgery: having the catheter removed at the clinic or removing it themselves at home. The focus was on people living in rural areas who may have trouble traveling to a…

This study tests a goal-setting program for adults with knee problems like arthritis or injuries. Participants work with their surgeon to create specific, measurable goals and track progress. The aim is to see if this approach helps patients achieve their treatment goals and impr…

This study tests a home-based program called HOBSCOTCH-PTE for people with epilepsy caused by a traumatic brain injury. The program aims to improve quality of life, memory, and thinking skills, and also helps support their caregivers. The study includes 160 adults with post-traum…

This pilot study tests whether a telehealth program called HOBSCOTCH-PACS can help people with long COVID manage memory and thinking problems. Ten participants will attend nine virtual coaching sessions and complete questionnaires about their quality of life and cognitive functio…

This study looks at whether a lower dose of Botox injected into the bladder can effectively treat urgent, frequent bladder leaks in women aged 70 and older. The goal is to reduce symptoms and improve quality of life while possibly causing fewer side effects than the standard dose…

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

This study tests a new collapsible pessary (Reia) for women with pelvic organ prolapse. The goal is to see if it allows patients to care for their prolapse on their own, instead of needing to visit a doctor 2-4 times per year. About 120 current pessary users will try the device a…

This pilot study tests a home-based program called HOBSCOTCH, designed to help people with multiple sclerosis manage memory and thinking problems. Eleven participants will attend virtual coaching sessions and complete questionnaires about their quality of life and cognitive funct…

This study tests a new web-based tool designed to help people considering metoidioplasty or phalloplasty (gender-affirming surgeries) make more informed decisions. About 140 participants will either use the tool or receive standard care, then share feedback on how clear and helpf…

This study compares two methods to confirm that an epidural needle is in the right spot: a pressure-based waveform analysis and traditional X-ray guidance. About 160 adults having planned surgery will receive both checks. The goal is to see if the pressure test is as accurate as …