Dartmouth-hitchcock Medical Center

This study tests a laser treatment for tumors that have spread to the spine. The goal is to see if the laser can control tumor growth as well as traditional surgery, but with less risk. About 25 people with spine tumors will receive the laser treatment and be followed with MRI sc…

This study tests whether giving a second, focused course of radiation to the breast is safe and effective for women whose breast cancer has returned more than a year after initial treatment. About 30 participants will receive accelerated partial breast irradiation. The goal is to…

This pilot study will test whether flushing the chest tube with saline alone can treat complicated pleural infections (fluid buildup around the lungs). If saline doesn't work, patients will receive stronger clot-busting drugs (fibrinolytics) or surgery. The study will track how l…

This early-phase trial tests a fluorescent dye called ABY-029 that may help surgeons see head and neck cancer during surgery. About 24 adults with head and neck squamous cell carcinoma will receive a tiny amount of the dye before surgery. Researchers will check safety and find th…

This trial investigates whether a home-based self-management program called HOBSCOTCH can improve thinking, memory, and quality of life in young adults (ages 18–29) and youth (ages 13–17) with epilepsy. Participants attend nine weekly one-on-one coaching sessions by phone or comp…

This pilot study tests a structured agenda-setting tool designed for children with medical complexity and their families during hospital stays. The tool lets patients and care partners choose priority topics before multidisciplinary family meetings. Researchers want to see if the…

This study investigates whether DNA methylation patterns in blood immune cells can predict which patients with Polymyalgia Rheumatica (PMR) will relapse when corticosteroid treatment is tapered. Researchers will analyze blood samples from 50 PMR patients to see if specific immune…

This study tests a tablet-based program called Plan & Protect for teens aged 12-17 who visit rural emergency departments with suicidal thoughts or self-harm. The program helps teens and their caregivers create a personalized safety plan and reduce access to firearms and medicatio…

This study tests whether a special light treatment can help prevent infections in people with bone-anchored prostheses (artificial limbs attached directly to the bone). Ten participants will apply a medicated cream to the skin where the metal rod comes out, then use a light devic…

This study tests whether giving people a one-page planning guide along with their at-home colorectal cancer screening kit (FIT) helps them actually complete and return the test. About 1,600 adults aged 45-75 from primary care clinics will be randomly assigned to receive either th…

This study looks at better ways to screen caregivers of people with dementia for depression and connect them to online treatment. About 15 adult caregivers who show mild depression symptoms will test a new app. The goal is to see if the approach is easy to use and helps more peop…

This study looks at whether a type of brain stimulation called transcranial magnetic stimulation can help people with OCD shift their behavior more flexibly. It involves 12 participants who will receive three daily sessions of stimulation. The goal is to see if the procedures are…

This study will test whether using virtual reality headsets raises the risk of seizures in adolescents and adults with epilepsy. Forty participants will wear a VR headset while their brain activity is recorded with EEG, comparing periods with the display off, on, and with hand co…

This pilot study will test whether a smartwatch can measure pain levels in 15 people with knee osteoarthritis. Participants will wear an Embrace Plus smartwatch that tracks electrodermal activity (skin signals) while reporting their pain during standard physical tests. The goal i…

This study looks at whether lidocaine, a numbing medicine, changes the signals used to monitor nerves during spine surgery. 44 adults having spine surgery will get either lidocaine or a placebo. The goal is to see if lidocaine affects the nerve monitor readings, which could help …