Laughing gas may take the ouch out of Kids' needle sticks

NCT ID NCT07159425

Completed Symptom relief Sponsor: Mother and Child Health Institute of Serbia Dr Vukan Cupic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether breathing a 50:50 mix of oxygen and nitrous oxide (laughing gas) can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, stitches, or tube placements. Researchers observed 100 children and measured their pain using age-appropriate scales. The goal was to see if the gas helps kids cooperate and feel less distress without serious side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 50:50 oxygen-nitrous oxide gas mixture
What this could lead to: If effective, this gas mix could become a standard option to help children stay calm and comfortable during minor medical procedures without needles or heavy sedation.
What could go wrong: This is a small, completed observational study, not a large trial. The gas may not work for all children, and side effects like low blood pressure or oxygen drops are possible.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY PAIN SEDATION

Contacts and locations

Locations

Institute for mother and child health care

Belgrade, Serbia

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Other studies related to the condition(s) this trial covers.