SEDATION

This study tests whether remimazolam, a newer sedative, can improve outcomes for ICU patients who need a breathing tube and sedation. Researchers will compare remimazolam to standard sedatives in 80 adults. The main goal is to see if patients spend more days free from the ventila…

This study tests whether giving sedation as a gas (isoflurane) instead of through an IV (propofol) helps critically ill patients on breathing machines recover faster. About 620 adults in the ICU who need deep sedation will be randomly assigned to one of the two methods. The main …

This study tests whether using a Bispectral index (BIS) monitor, which tracks brain activity, can help doctors better manage sedation in patients on breathing machines. Researchers will compare how long patients stay on the ventilator, their ICU stay, and the amount of sedation d…

This study tests whether remimazolam besylate works as well as dexmedetomidine for keeping patients lightly sedated while on a breathing machine after non-cardiac surgery. About 306 adults aged 18–64 will take part across five hospitals in China. The goal is to see if remimazolam…

This study compares three sedation approaches—using dexmedetomidine, propofol, or both—during cataract surgery in 1,000 adults. Researchers will measure how well each method sedates patients, affects heart rate and blood pressure, and causes side effects like nausea. The goal is …

This program offers inhaled isoflurane, given through a special device, to sedate adult ICU patients on breathing machines who are difficult to sedate with usual IV medicines. It aims to help patients who remain agitated or at risk of harming themselves despite standard treatment…

This study compares two ways to sedate children before cleft palate repair: a combination of two drugs (dexmedetomidine and ketamine) given through a nebulizer versus dexmedetomidine alone. The goal is to see which approach works better for calming the child before surgery and pr…

This study looks at whether the amount of light in the room changes how much anesthesia medicine people need during surgery. 66 adults having general anesthesia will be randomly assigned to wear an eye shield or not. Researchers will measure drug doses, time to fall asleep, and t…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This study will look at up to 1.2 million patients to see how long they fast before surgery and whether longer fasting leads to problems like nausea, low blood pressure, or kidney injury. Researchers want to find out if current fasting guidelines are too strict and might actually…

This study compares two computer programs (Eleveld and Schnider) that help doctors give the sedative propofol to patients on breathing machines in the ICU. The goal is to see which program keeps patients at the right sedation level more accurately and safely. Researchers will mon…