SEDATION

This study compares two ways to sedate children before cleft palate repair: a combination of two drugs (dexmedetomidine and ketamine) given as a mist versus dexmedetomidine alone. The goal is to see which approach works better for helping kids relax before surgery and preventing …

This study tests whether a newer sedative called ciprofol works as well as the standard drug propofol for keeping ICU patients calm while on a breathing machine, but with fewer side effects like dangerously low blood pressure. About 366 adults who need sedation for 6-24 hours wil…

This study tests if giving sedation through inhaled gas (isoflurane) helps critically ill patients spend less time on breathing machines compared to standard IV sedation (propofol). About 620 adults in the ICU who need deep sedation will be randomly assigned to one of the two met…

This study compares two medications used to sedate patients during endoscopy (a procedure to look inside the body). The goal is to see if a newer drug called remimazolam works as well as or better than the standard drug propofol. About 100 adults having planned endoscopy will tak…

This study looks at whether a drug called remazolam besylate is as good as or better than another sedative (dexmedetomidine) for keeping critically ill patients calm and comfortable while they are on a breathing machine after non-cardiac surgery. About 306 adults aged 18-64 who n…

This study compares three sedation methods (dexmedetomidine, propofol, or both) in 1,000 adults having cataract surgery. The goal is to see which approach provides the best sedation with the fewest side effects like low blood pressure or nausea. All participants will also receive…

This program offers a special inhaled sedative (isoflurane) given through a device called Sedaconda ACD-S for adults in the intensive care unit who are on breathing machines and are very difficult to sedate with usual medicines. The goal is to help these patients stay calm and sa…

This study tests a new brain activity monitor in 100 ICU patients who are on breathing machines and sedatives. The monitor uses a simple forehead patch to track brain signals and see if it matches standard checks for sedation and delirium. The goal is to find a better way to moni…

This study looks at two computer programs (Eleveld and Schnider) that help doctors give the right amount of propofol sedation to patients on breathing machines in the ICU. Researchers will check how well each program keeps patients at the right sedation level, how stable their he…

This study examines how long patients fast before surgery and whether that affects their recovery. Researchers will track 1.2 million people to see if longer fasting leads to problems like nausea, low blood pressure, or kidney injury. The goal is to improve fasting guidelines for…

This study looks at whether the amount of light in the operating room changes how much anesthesia medicine people need during surgery. 66 adults having general anesthesia will be randomly assigned to wear an eye shield or not. Researchers will measure drug doses, time to fall asl…