Breathing in sedation: could a gas help ICU patients leave the ventilator faster?
NCT ID NCT07000526
First seen Jun 27, 2026 · Last updated Jun 30, 2026 · Updated 2 times
Summary
This study tests whether giving sedation as a gas (isoflurane) instead of through an IV (propofol) helps critically ill patients on breathing machines recover faster. About 620 adults in the ICU who need deep sedation will be randomly assigned to one of the two methods. The main goal is to see how many days they are alive and off the ventilator within the first 28 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Isoflurane (inhaled) and Propofol (intravenous)
- What this could lead to
- If it works, this could show that inhaled sedation helps patients come off ventilators faster and spend less time in the ICU.
- What could go wrong
- This is a phase 4 trial, but it's still early to know if inhaled sedation is truly better. Results may not apply to all ICU patients, and there are risks like breathing problems or heart issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for AIRWAY EXTUBATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hospital Arnau de Vilanova
NOT_YET_RECRUITINGLleida, Spain
-
Hospital Clínico Universitario de Valencia
RECRUITINGValencia, Spain
-
Hospital Galdakao-Usansolo Ospitalea
NOT_YET_RECRUITINGGaldakao, Vizcaya, Spain
-
Hospital Germans Trias i Pujol
RECRUITINGBadalona, Spain
-
Hospital Regional Universitario de Málaga
NOT_YET_RECRUITINGMálaga, Spain
-
Hospital Univeritario Puerta de Hierro
NOT_YET_RECRUITINGMadrid, Spain
-
Hospital Universitario Doctor José Molina Orosa
NOT_YET_RECRUITINGArrecife, Lanzarote-Canary Islands, 35500, Spain
-
Hospital Universitario Gregorio Marañon
RECRUITINGMadrid, Spain
-
Hospital Universitario Infanta Leonor
RECRUITINGMadrid, Spain
-
Hospital Universitario Joan XXIII
RECRUITINGTarragona, Spain
-
Hospital Universitario La Paz
RECRUITINGMadrid, 28029, Spain
-
Hospital Universitario Ramon y Cajal
NOT_YET_RECRUITINGMadrid, 28029, Spain
-
Hospital Universitario Rey Juan Carlos
RECRUITINGMadrid, Spain
-
Hospital Universitario Rio Hortega
RECRUITINGValladolid, Spain
-
Hospital Universitario Valle de Hebron
RECRUITINGBarcelona, Spain
-
Hospital Universitario de Albacete
NOT_YET_RECRUITINGAlbacete, Spain
-
Hospital Universitario de Bellvitge
RECRUITINGBarcelona, Spain
-
Hospital Universitario de Fuenlabrada
NOT_YET_RECRUITINGMadrid, 28029, Spain
-
Hospital Universitario de Jaen
NOT_YET_RECRUITINGJaén, Spain
-
Hospital Universitario de Toledo
NOT_YET_RECRUITINGToledo, Spain
-
Hospital Universitario de la Princesa
RECRUITINGMadrid, Spain
-
Hospital Vega Baja
RECRUITINGOrihuela, Alicante, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a gentle oxygen boost make lung biopsies safer and faster?
- A Mother's voice as medicine? trial tests comforting effect on ventilated children
- A single score may spot breathing trouble before it's too late in sedated children
- New sedation cocktail aims to protect elderly patients during routine scopes
- Which sedation drug is safer for mom and baby during C-Section?
- Heart risk under the knife: new study tracks anesthesia dangers in rare cardiac condition