SEDATION

This study tested whether playing music can improve sedation for children undergoing painful procedures in the emergency department. 88 children received standard sedative medication plus music. The goal was to see if music helps them stay calmer and more comfortable. Results foc…

This study tested whether listening to music can lower stress and inflammation in sedated adults on breathing machines in the intensive care unit (ICU). Researchers measured stress hormones and inflammatory markers in the blood of 110 patients before and after a one-hour music se…

This study looked at whether a 50% oxygen and 50% nitrous oxide (laughing gas) mixture can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, catheter placement, or stitch removal. Researchers observed 100 children and measured pain using a…

This study looked at two common ways to calm children before an endoscopy: a calming nose spray (dexmedetomidine) or watching short videos. Researchers measured anxiety levels in 50 children aged 2-12 at different times before the procedure. The goal was to see which method worke…

This study tested two different sedation combinations to see which works best for removing a Double-J ureteral stent, a common urology procedure. Sixty adults received either propofol alone or propofol plus dexmedetomidine or midazolam. The goal was to find the safest and most ef…

This study tested whether an inhaled anesthetic, isoflurane, given through a special device works as well as the standard IV drug propofol for keeping ICU patients calm while on a breathing machine. About 282 adults who needed sedation for over 12 hours took part. The goal was to…

This study tested whether an inhaled sedative called isoflurane works better than the standard IV drug propofol for keeping ICU patients calm while on a breathing machine. About 277 adults who needed sedation for at least 12 hours took part. The goal was to see which method keeps…

This study tested whether adding a painkiller called nefopam to standard care could lower the amount of strong opioids needed by ICU patients on breathing machines. 60 adults were randomly assigned to receive either nefopam or a placebo alongside usual sedation. The goal was to s…

This study tested whether a lidocaine drip can reduce muscle spasms in the duodenum during a procedure called ERCP, which looks at the bile and pancreatic ducts. 120 adults were randomly given lidocaine or a placebo. The goal was to see if lidocaine could lower the need for extra…

This study looked at 164 adults aged 65 and older who had a colonoscopy with sedation. Researchers wanted to see if frailty and the type of sedative used (propofol or dexmedetomidine) affected thinking and memory after the procedure. Participants took a simple mental test before …

This study tested whether giving sedation through inhalation (breathing it in) instead of standard IV drugs could reduce the energy delivered to the lungs by the ventilator (mechanical power) in 40 ICU patients. Lower mechanical power may mean less lung injury and better outcomes…

This study tested whether giving older adults a pill (oral sedation) instead of medicine through an IV (intravenous sedation) before cataract surgery is a good option. Twenty people aged 65 and older took part. The goal was to see if it's possible to run a larger study comparing …

This study looked at 120 women having minor gynecologic surgery to see how different sedation drugs affect early mental recovery. Participants received one of three drug combinations: propofol-fentanyl, ketamine-fentanyl, or a mix of all three. Researchers measured thinking abili…

This study looked at whether a special brain monitor (4-channel EEG) can help doctors give just the right amount of sedation during a procedure called ERCP, which examines the bile and pancreatic ducts. 84 adults having elective ERCP took part. The goal was to see if using the mo…