SEDATION

This study compares two medications—dexmedetomidine and low-dose ketamine—given as a single dose before a planned C-section under spinal anesthesia. Both groups then receive a steady infusion of dexmedetomidine to keep them comfortable. Researchers will measure how well each drug…

This study compares a new sedative called ciprofol to the standard drug propofol in 366 ICU patients who need a breathing tube. The goal is to see if ciprofol can sedate patients just as well but with fewer episodes of dangerously low blood pressure. Participants will be randomly…

This study tested three sedation approaches for removing a Double-J ureteral stent, a common procedure. Sixty adults received either propofol alone, propofol plus dexmedetomidine, or propofol plus midazolam. Researchers measured total propofol use and sedation levels to find the …

This study tested whether giving lidocaine through an IV can reduce muscle spasms in the duodenum during ERCP, a procedure to examine bile ducts. 120 adults were randomly assigned to receive lidocaine or a placebo. The goal was to see if lidocaine lowers the need for extra spasm-…

This study tested whether an inhaled anesthetic gas, isoflurane, given through a special device (Sedaconda ACD-S), works as well as the standard IV drug propofol for keeping ICU patients calm while on a breathing machine. The trial included 282 adults expected to need sedation fo…

This study tested whether a single 60-minute session of relaxing music (60-80 bpm) played through headphones could reduce stress and inflammation in 110 sedated adults on breathing machines in the ICU. Researchers measured stress hormones and inflammatory markers in blood before …

This study tested whether an inhaled anesthetic gas, isoflurane, given through a special device (Sedaconda ACD-S), works better than the standard IV drug propofol for keeping ICU patients comfortably sedated while on a breathing machine. The trial involved 277 adults expected to …

This study looked at whether breathing a 50:50 mix of oxygen and nitrous oxide (laughing gas) can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, stitches, or tube placements. Researchers observed 100 children and measured their pain usi…

This study tested whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce the need for fentanyl (a strong opioid) in critically ill patients on mechanical ventilators. Sixty adults were randomly assigned to receive either nefopam plus standard care or standa…

This study tested whether playing music during medical procedures helps children stay calm and comfortable while under sedation in the emergency department. Researchers enrolled 88 children aged 0-14 who needed sedation for painful procedures. Half received standard care plus mus…

This study looked at two common methods to reduce anxiety in children aged 2-12 before an endoscopy: watching short videos or receiving a nasal spray of dexmedetomidine. Researchers measured anxiety levels at different times before the procedure. The goal was to see which approac…

This study tested whether giving a gas sedative (isoflurane) instead of standard IV drugs could reduce the energy delivered to the lungs by the breathing machine in 40 ICU patients. The goal was to see if this approach might lower the risk of lung injury. The trial was small and …

This pilot study tested whether giving a sedative pill (alprazolam) before cataract surgery works as well as IV sedation (midazolam) in adults 65 and older. Twenty participants were randomly assigned to one of the two approaches, and researchers measured how well their thinking a…

This study looked at 164 adults aged 65 and older who had a colonoscopy with sedation. Researchers compared two common sedatives—propofol and dexmedetomidine—to see how they affected thinking and memory. They also checked whether frailty played a role. Participants took a simple …

This study looked at 120 women having minor gynecologic surgery to see how different sedation drugs affect thinking skills right after the procedure. Patients received one of three drug combinations, and their mental function was tested before and after surgery. The goal was to f…

This study tested whether a 4-channel EEG brain monitor can help doctors give the right amount of sedation during ERCP, a procedure to treat bile duct problems. 84 adults received propofol sedation, and the monitor tracked their brain activity to guide dosing. The goal was to kee…