New inhaled sedative could change ICU care

NCT ID NCT05327296

Completed Symptom relief Sponsor: Sedana Medical Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether an inhaled anesthetic gas, isoflurane, given through a special device (Sedaconda ACD-S), works as well as the standard IV drug propofol for keeping ICU patients calm while on a breathing machine. The trial included 282 adults expected to need sedation for over 12 hours. Researchers measured how often sedation stayed in the target range and whether opioid use could be reduced.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: isoflurane (inhaled anesthetic gas)
What this could lead to: If it works, this could offer a new sedation option for ICU patients on ventilators, potentially reducing opioid use.
What could go wrong: This is a completed phase 3 trial, but results may not show a clear advantage over propofol. Risks include side effects like low blood pressure or breathing issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEDATION

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Henry Ford Health System

Detroit, Michigan, 48202, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Health Services

Long Beach, California, 90807, United States
Memorial Hermann Health Services

Houston, Texas, 77030, United States
Ohio State University

Columbus, Ohio, 43210, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Stanford University

Redwood City, California, 94063, United States
The Cooper Health System

Camden, New Jersey, 08103, United States
The New York and Presbyterian Hospital

New York, New York, 10032, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
University of California, Los Angeles

Los Angeles, California, 90095, United States
University of California, San Diego

San Diego, California, 92023, United States
University of Miami

Coral Gables, Florida, 33146, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
Virginia Commonwealth University

Richmond, Virginia, 23284, United States

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