Could a simple gas reduce lung damage in ventilator patients?

NCT ID NCT05559970

Completed Knowledge-focused Sponsor: Mahidol University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether giving a gas sedative (isoflurane) instead of standard IV drugs could reduce the energy delivered to the lungs by the breathing machine in 40 ICU patients. The goal was to see if this approach might lower the risk of lung injury. The trial was small and only measured short-term changes, so more research is needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: isoflurane
What this could lead to: If it works, this could point toward a better sedation method that reduces lung injury and improves recovery for ICU patients on ventilators.
What could go wrong: This is a very small pilot study (40 patients) that only looks at short-term changes in lung mechanics, not long-term outcomes. The results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lung injury Lung Injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ICU LUNG INJURY MECHANICAL POWER MECHANICAL VENTILATION SEDATION

Contacts and locations

Locations

Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok Noi, Bangkok, 10700, Thailand

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