New inhaled sedative could change ICU care

NCT ID NCT05312385

First seen Apr 15, 2026 · Last updated May 14, 2026 · Updated 5 times

Summary

This study tested whether an inhaled sedative called isoflurane works better than the standard IV drug propofol for keeping ICU patients calm while on a breathing machine. About 277 adults who needed sedation for at least 12 hours took part. The goal was to see which method keeps patients at the right sedation level more consistently and safely.

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Contacts and locations

Locations

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Intermountain Health Care Health Services

    Salt Lake City, Utah, 84111, United States

  • MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • The Brigham and Women´s Hospital

    Boston, Massachusetts, 02115, United States

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • University of Chicago

    Chicago, Illinois, 60637, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45219, United States

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • University of Virginia

    Charlottesville, Virginia, 22903, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.