New inhaled sedative could change ICU care

NCT ID NCT05312385

Completed Symptom relief Sponsor: Sedana Medical Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether an inhaled anesthetic gas, isoflurane, given through a special device (Sedaconda ACD-S), works better than the standard IV drug propofol for keeping ICU patients comfortably sedated while on a breathing machine. The trial involved 277 adults expected to need sedation for more than 12 hours. Researchers measured how often sedation stayed in the target range and whether opioid use could be reduced.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: isoflurane (inhaled anesthetic gas)
What this could lead to: If it works, this could offer a new way to sedate ICU patients on ventilators that may reduce opioid use compared to current standard care.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The benefit over propofol may be small, and inhaled isoflurane requires special equipment and monitoring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEDATION

Contacts and locations

Locations

Emory University

Atlanta, Georgia, 30322, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Intermountain Health Care Health Services

Salt Lake City, Utah, 84111, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
The Brigham and Women´s Hospital

Boston, Massachusetts, 02115, United States
The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
University of Chicago

Chicago, Illinois, 60637, United States
University of Cincinnati

Cincinnati, Ohio, 45219, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
University of Virginia

Charlottesville, Virginia, 22903, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.