New inhaled sedative could change ICU care
NCT ID NCT05312385
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether an inhaled anesthetic gas, isoflurane, given through a special device (Sedaconda ACD-S), works better than the standard IV drug propofol for keeping ICU patients comfortably sedated while on a breathing machine. The trial involved 277 adults expected to need sedation for more than 12 hours. Researchers measured how often sedation stayed in the target range and whether opioid use could be reduced.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
isoflurane (inhaled anesthetic gas)
What this could lead to
If it works, this could offer a new way to sedate ICU patients on ventilators that may reduce opioid use compared to current standard care.
What could go wrong
This is a completed Phase 3 trial, but results are not yet published. The benefit over propofol may be small, and inhaled isoflurane requires special equipment and monitoring.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Emory University
Atlanta, Georgia, 30322, United States
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Intermountain Health Care Health Services
Salt Lake City, Utah, 84111, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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The Brigham and Women´s Hospital
Boston, Massachusetts, 02115, United States
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The Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Tufts Medical Center
Boston, Massachusetts, 02111, United States
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University of Chicago
Chicago, Illinois, 60637, United States
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University of Cincinnati
Cincinnati, Ohio, 45219, United States
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University of Colorado Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Virginia
Charlottesville, Virginia, 22903, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States