New painkiller could cut opioid use in ICU patients
NCT ID NCT05071352
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce the need for fentanyl (a strong opioid) in critically ill patients on mechanical ventilators. Sixty adults were randomly assigned to receive either nefopam plus standard care or standard care alone. The goal was to see if nefopam could provide effective pain relief while lowering opioid doses and their side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nefopam (a non-opioid painkiller)
What this could lead to
If it works, this could offer a way to reduce opioid use in ICU patients on ventilators, potentially lowering side effects like addiction or breathing problems.
What could go wrong
This is a small, single-center trial with only 60 patients, so results may not apply broadly. Nefopam may not reduce opioid use as hoped, and side effects like nausea or sweating are possible.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cairo University Hospitals (Kasr Alainy)
Cairo, Egypt