SEDATION

This study tests whether a new combination of sedative and painkiller drugs can make deep sedation safer for elderly patients (ages 60-90) undergoing a procedure called ERCP, which treats bile duct problems. The goal is to reduce breathing complications and speed up recovery comp…

This study tests whether letting children watch a virtual reality (VR) tour of an MRI scanner before their real scan can reduce anxiety, movement, and the need for sedation. About 150 children aged 5 to 10 having their first MRI will be randomly assigned to either a VR tour at ho…

This study tests whether a structured palliative care plan, combined with staff training, can improve the end-of-life experience for ICU patients on breathing machines when life support is withdrawn. About 720 adults in ICUs will be involved, comparing the new approach to usual c…

This study tests whether giving flumazenil after hip replacement surgery can prevent confusion and memory problems. 150 adults having hip surgery under spinal anesthesia will receive either flumazenil or a placebo. Researchers will check thinking skills and delirium rates in the …

This study tests whether using a brain activity monitor (BIS) can help doctors give less sedation to patients on breathing machines in the ICU. About 30 adults who are on a breathing machine and receiving sedation will be randomly assigned to either BIS monitoring or standard car…

This study compares two sedation approaches—atomized midazolam with fentanyl versus dexmedetomidine—for patients aged 2 to 60 undergoing medical procedures. Researchers will measure how deeply sedated patients become, how quickly they recover, and any side effects. The goal is to…

This study tests whether a nasal spray containing dexmedetomidine can safely sedate adults before surgery when little monitoring is available. About 564 participants will receive either the spray or a placebo 45 minutes before anesthesia. Researchers will track breathing and hear…

This study tests two different nasal sprays (dexmedetomidine and ketamine) to see which one works better at calming children aged 2-6 before surgery. The goal is to help kids feel less anxious and separate more easily from their parents. The study will enroll 60 children and meas…

This study will compare two sedative drugs, Remimazolam and Dexmedetomidine, in 60 adults undergoing Drug-Induced Sleep Endoscopy (DISE) for obstructive sleep apnea. The goal is to see which drug provides more stable sedation with fewer side effects like low heart rate or low blo…

This study watches brain activity (EEG) in 330 people during routine anesthesia or sedation to see how it relates to drug levels and patient responses. It includes children (some with autism), adults over 70, and adults having sedation for endoscopy. No treatments are changed—the…