Could skipping opioids make endoscopy safer and more comfortable?
NCT ID NCT07649746
First seen Jun 23, 2026 · Last updated Jun 23, 2026
Summary
This study will test whether using only dexmedetomidine (an opioid-free sedative) during endoscopy procedures like colonoscopy and ERCP can reduce common side effects such as nausea, dizziness, and drowsiness compared to a standard opioid-based combination. Eighty adults scheduled for these procedures will be randomly assigned to one of two sedation groups. The goal is to see if avoiding opioids leads to a smoother recovery and higher satisfaction for both patients and staff.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine and remifentanil
What this could lead to
If successful, this could show that opioid-free sedation is a safer, more comfortable option for routine endoscopy procedures.
What could go wrong
This is a small, early-stage study with only 80 participants, so results may not apply to everyone. The opioid-free approach might not control pain as well as the combination.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.