Could skipping opioids make endoscopy safer and more comfortable?

NCT ID NCT07649746

Not yet recruiting Symptom relief Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test whether using only dexmedetomidine (an opioid-free sedative) during endoscopy procedures like colonoscopy and ERCP can reduce common side effects such as nausea, dizziness, and drowsiness compared to a standard opioid-based combination. Eighty adults scheduled for these procedures will be randomly assigned to one of two sedation groups. The goal is to see if avoiding opioids leads to a smoother recovery and higher satisfaction for both patients and staff.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexmedetomidine and remifentanil
What this could lead to: If successful, this could show that opioid-free sedation is a safer, more comfortable option for routine endoscopy procedures.
What could go wrong: This is a small, early-stage study with only 80 participants, so results may not apply to everyone. The opioid-free approach might not control pain as well as the combination.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLONOSCOPY ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) ENDOSCOPY SEDATION

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