ANXIETY

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This pilot study is testing whether adults with serious mental health issues like psychosis, anxiety, or depression can receive hospital-level care in their own homes. Researchers will see how many people are eligible and willing to try this approach. The goal is to offer a safe,…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study tests a phone-based care management program for adults with depression, anxiety, or risky drinking. Participants get regular check-ins and support from a mental health technician, while their primary care doctor receives treatment recommendations. The goal is to see if…

This study tests whether painting roofs with a special reflective coating can lower indoor temperatures and improve mental health. About 800 people in Ahmedabad, India, who live in homes with poor insulation will be randomly assigned to get a cool roof or not. Researchers will me…

This study compares a structured group exercise program called Braining with standard advice to exercise on your own. Over 12 weeks, 208 psychiatric patients will attend up to three clinician-led exercise sessions per week. Researchers will measure physical activity, depressive s…

This study tests whether a health promotion program can prevent anxiety and depression in older Latino adults who are at risk. 240 participants will either join a program with group walks and social sessions led by a community health worker, or attend a healthy lifestyles educati…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

This study tests whether smelling essential oils during skin surgery can reduce the unpleasant smell of burnt flesh from electrocautery and lower patient anxiety. About 111 adults having same-day skin procedures will be randomly assigned to receive either a real essential oil inh…

This study tests whether a smartphone app called AIM+ can help juvenile justice officers and other professionals who work with youth in the legal system manage chronic stress, anxiety, and burnout. Over 30 days, participants use the app for short guided meditations and videos. Th…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This study looks at two ways to lower anxiety in children aged 3 to 10 who need surgical pins removed from an elbow fracture. One approach removes the pins right after the cast comes off, before an X-ray, instead of after. The other uses a virtual reality headset during the pin r…

This study looks at whether a peer support program is acceptable and helpful for people with mild depression or anxiety who are starting or receiving hormone care. One hundred participants are randomly assigned to either the peer support group or usual care. The program includes …

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study compares two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will take part, and researchers will measure pain, mood, and sleep quality. The goal is to find simple, at-home way…

This study tests a 7-session, peer-led self-management program for 234 cancer survivors who recently finished treatment with curative intent. The program aims to reduce anxiety and depression by teaching symptom management skills in a group setting. Participants are from central …

This study tests whether a new type of group therapy, called Group Cognitive Evolutionary Therapy, can help reduce symptoms of depression and anxiety. Sixty-four adults with mild to severe depression will either receive two full days of therapy or be placed on a waiting list. Res…

This study tests whether a new therapy called Emotional Resolution (EmRes) can help reduce anxiety in healthcare workers. About 150 hospital workers with mild to moderate anxiety will either receive EmRes or a mindfulness-based gratitude exercise. The goal is to see if EmRes lead…

This study tests a single online session that teaches a simple coping skill to youth ages 9-17 who are on a waitlist for therapy. The goal is to see if this quick digital tool can help ease symptoms of anxiety, depression, and stress while they wait. About 226 youth and their par…

This study tests whether a community-based music mindfulness program can reduce anxiety and depression in children aged 8-12 with ADHD or anxiety. Participants attend bi-weekly sessions for 8 weeks, wear fitness trackers, and complete surveys. The goal is to see if this approach …

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. Ninety adults will receive one of the drugs or a placebo before spinal anesthesia. Researchers will measure anxiety levels and pain sc…

This study tests a digital cognitive behavioral therapy program (SilverCloud) for Spanish-speaking adults with depression or anxiety. 426 participants will either use the program on their own or get extra support from a peer coach via phone or messaging. The goal is to see if add…

This pilot study tests whether an 8-week mindfulness program (MBSR) can reduce anxiety, depression, and stress in people with COPD who are already in pulmonary rehab. About 44 participants will be followed for 12 months. The goal is to see if this mind-body approach improves emot…

This study tests whether a physical activity program can help pregnant people with symptoms of depression or anxiety feel better. 88 participants will be given a step goal and wear an activity tracker. The program includes weekly reminders and motivational coaching every two week…

This study tests whether an online cognitive behavior therapy (CBT) program can help children aged 8 to 17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. The st…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study tests an online cognitive behavioral therapy (CBT) program for university students with mild depression or anxiety. Two hundred students who previously took a mental health survey will receive a tailored internet treatment. The goal is to see if this e-health approach …

This study tests whether listening to specific sound frequencies for just 9 minutes a week can improve mental health. 110 adults with mild anxiety, stress, or depression will either sit in a special sound chamber or use headphones. The goal is to see if this simple, drug-free app…

This study tests whether using a virtual reality headset during PICC line placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if this non-drug appro…

This study looks at whether cancer patients can use a self-guided meditation program at home to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or gentle movement for two weeks. The goal is to see if this simple, low-cost approach is pract…

This study tests whether an internet-based self-help program called VIVIM can help university students with anxiety and depression. About 108 students will be randomly assigned to use VIVIM or receive usual support from their university counseling service. They will fill out ques…

This study tests a program that combines family group sessions with a virtual peer mentoring program for US-born teens (ages 14-17) whose parents resettled as refugees. The goal is to reduce symptoms of PTSD, depression, anxiety, and behavior problems caused by intergenerational …

This study planned to test whether a lidocaine nerve block (SPG block) could reduce anxiety in adults at electronic dance music festivals, compared to a saline placebo. The trial was withdrawn before enrolling any participants, so no data were collected. The approach was experime…

This study tests a brief digital mental health program for people on waiting lists for psychological treatment. About 80 participants will be randomly assigned to one of four groups: a short program (30-40 minutes), a longer version, or control conditions. The main goal is to see…

This study tests a 12-session group therapy program (G-BCBT) for active duty military personnel who have recent suicidal thoughts or a recent suicide attempt. The therapy teaches emotion regulation, cognitive flexibility, and relapse prevention skills. Researchers will measure ch…

This study tests whether combining a mild electrical brain stimulation (tDCS) with virtual reality meditation can help ease anxiety. 52 adults with generalized anxiety disorder or related conditions will receive 12 sessions over two weeks. Researchers will measure anxiety levels …

This study tests whether writing about imagined future scenarios (worst-case, best-case, or neutral) can reduce social anxiety symptoms. 270 adults with elevated social anxiety will complete three online writing sessions over three weeks. Researchers will measure changes in anxie…

This study looks at whether using a mindfulness app on a smartphone for 8 weeks can improve mental health in Korean immigrants aged 60 and older. Participants use the app for about 10-15 minutes daily and have weekly check-ins. The goal is to see if the app is easy to use and hel…

This study aimed to see if having a parent appear on a video call during anesthesia induction could reduce children's anxiety as effectively as the sedative midazolam. It was designed for children aged 4 to 8 undergoing outpatient surgery. However, the study was withdrawn before …

This study tests if a therapy called FIRST, which uses five key principles to help youth manage negative emotions, works better than standard therapy. About 212 youth aged 7 to 15 with anxiety, depression, trauma, or behavior problems will take part. The goal is to see if FIRST i…

This study tests whether a device called CES (cranial electrotherapy stimulation) can reduce anxiety symptoms in 200 active-duty military members and their families. Participants receive either real CES or a sham (placebo) device to see if the gentle electrical pulses truly help.…

This study tests whether a gentle ultrasound beam aimed at the brain can reduce anxiety. 44 people with high or low anxiety will receive either real or fake ultrasound while their reactions to stressful tasks are measured. The goal is to see if this noninvasive technique can damp…

This study aims to help mothers of babies in intensive care cope with depression, anxiety, and stress while also addressing basic needs like food and housing. About 200 caregivers of infants up to 6 months old will receive emotional support and referrals to community resources. T…

This study tests an accelerated version of a brain stimulation treatment called TMS for people with depression and anxiety. Researchers want to find the best dose to reduce symptoms. About 70 adults will take part, and the study measures changes in mood using standard questionnai…

This small, early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who also had significant anxiety or agitation. The goal was to see if the treatment could reduce these behavioral sy…

This study tests whether a fruit compote made with maqui berry, prebiotics, and probiotics can reduce anxiety and inflammation in 30 university students aged 18-40. Participants eat the compote as part of their normal diet, and researchers measure changes in anxiety levels, stres…

This pilot study tests a therapy called Positive Affect Treatment (PAT) for Spanish-speaking adults with depression, anxiety, and low positive affect (a lack of joy or interest). Twelve participants will attend 15 therapy sessions over about 4 months, focusing on pleasant activit…

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This study is testing whether a virtual, personalized music-based relaxation program can help reduce anxiety in teens and young adults who have finished cancer treatment. About 50 participants aged 15-39 with anxiety will take part in 8 weekly 45-minute sessions. The goal is to s…

This study looks at whether watching immersive videos before open-heart surgery can lower patients' anxiety and improve their recovery. About 200 adults scheduled for elective heart surgery will take part. Researchers will measure anxiety using questionnaires and vital signs befo…

This study tests whether a mindfulness-based childbirth and parenting class can lower anxiety in pregnant women. Sixty women with elevated worry will be randomly assigned to either the mindfulness class or a standard childbirth education class. Researchers will track changes in a…

This study tests whether a 5-week heart rate variability biofeedback program can lower stress and anxiety in 50 dentistry students moving from classroom to clinic. Participants in the training group practice slow breathing with real-time feedback, while a control group receives n…

This study tests whether progressive relaxation exercises and planned education can reduce menopause symptoms, stress, and anxiety in menopausal women. About 144 women will participate, with some receiving the relaxation and education program and others not. The goal is to see if…

This study tests a device called Cereset that plays tones to mirror your brainwaves, aiming to reduce stress, anxiety, insomnia, and depression. About 40 nurses from one hospital unit will use the device. The goal is to see if it improves their well-being and job performance.

This study tests whether a mobile app called PTSD Coach, with or without brief clinician support, can reduce PTSD, anxiety, depression, and sleep problems in World Trade Center responders living in Florida. About 120 English- or Spanish-speaking responders will be randomly assign…

This study looks at whether one art therapy session can improve mood and reduce symptoms like pain and anxiety in adults receiving palliative care. Twenty patients in a Canadian hospital will fill out short questionnaires before and after a 30-60 minute art session. The goal is t…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This pilot study tested whether kava, a herbal supplement, could safely reduce anxiety and stress in 43 cancer survivors who had completed treatment. Participants took either kava or a placebo for 14 days, then switched after a washout period. The trial is currently suspended, an…

This study tests whether a virtual, community-based program combining music and mindfulness can help reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if these culturally relevant activ…

This pilot study is testing a group-based cognitive-behavioural therapy (CBT) for people with generalized anxiety disorder (GAD) who have difficulty tolerating uncertainty. The treatment focuses on helping participants face uncertain situations through behavioural experiments. Th…

This study looks at whether following an anti-inflammatory diet for 4 months can improve symptoms of anxiety and depression in 60 adults. Participants will either follow the special diet or their usual eating habits. The study also uses artificial intelligence to analyze speech a…

This study tests a special therapy program delivered over the internet for people with mild cognitive impairment or dementia who also feel anxious. The program uses cognitive behavioral therapy (CBT) techniques to help manage worry and fear. Researchers will measure changes in an…

This study looks at whether a simple hug from a family member before surgery can help lower anxiety and pain afterward. 160 adults having planned surgery will either hug for at least 20 seconds or follow standard care. Researchers will measure anxiety levels and pain scores to se…

This study looks at two simple ways to help children feel less anxious and in less pain when getting a tooth pulled. One method uses a fun video to distract them, and the other uses gentle pressure on a specific point on the hand. The study will include 69 healthy children aged 5…

This Mayo Clinic study tests whether reducing overall smartphone use and avoiding social media apps like Facebook, Instagram, and TikTok can lower anxiety symptoms in adults. One hundred participants with mild anxiety will be asked to change their phone habits, and their anxiety …

This study tests a small vibrating device held near the skin during needle sticks (like IVs or blood draws) to see if it lowers pain and anxiety. About 1,100 children and adults will take part. Researchers will watch and ask about discomfort to see if the buzz helps people feel c…

This study tests a 7-week group physical activity program called Confident, Active and Happy Youth (CAHY) for young people aged 8-17 with anxiety or depression. The program includes fun, non-competitive activities led by a therapist. Researchers want to see if it improves mood an…

This study tests whether watching calming nature videos with virtual reality glasses can lower pain and anxiety in people recovering from colorectal surgery. Sixty adults will be split into two groups: one group uses the VR glasses before and after surgery, while the other receiv…

This study looks at whether breathing in aromatherapy scents can help pregnant women feel less pain, worry, and nausea during labor. About 128 women in labor will either receive the scents or standard care. Researchers will compare their symptoms before and after to see if the sc…

This study planned to test whether virtual reality-based guided mindfulness meditation could help adults with anxiety, depression, stress, or pain feel better. Researchers wanted to see if using VR meditation was practical and if it improved mood and pain scores. However, the stu…

This study compares two non-invasive devices that stimulate the vagus nerve—one placed on the neck, the other on the ear—to see which better reduces physical discomfort and health-related anxiety in people with somatic symptom disorder. Sixty participants will try both devices in…

This study tests a topical patch called PEACE that uses gentle vibrations to help people feel less stressed or anxious. 150 adults aged 18 to 85 who have stress or anxiety will wear either the active patch or a sham (fake) patch for 14 days. Researchers will measure changes using…

This study looks at whether adding 10 grams of fibre to your daily diet for two weeks can improve mental wellbeing, including anxiety, stress, sleep, and mood. Researchers will track changes in 40 healthy adults aged 18-40 using questionnaires. It's a small, early-stage trial to …

This study looks at whether laughter yoga can lower exam anxiety and improve spirituality in nursing students. About 36 students will do laughter yoga twice a week for 4 weeks, while another group does nothing. Researchers will compare anxiety and spirituality scores before and a…

This study looks at whether spending time with a therapy dog can reduce anxiety and stress in graduate students. Thirty first-year grad students will either interact with a therapy dog or receive general health education. Researchers will measure stress through saliva cortisol le…

This study looks at whether two Akashic Records sessions can improve mental health in adults who have felt stressed, anxious, or down in the past year. Participants will attend private video sessions with a therapist and complete surveys about their mood and resilience. The goal …

This study tests a short, acceptance-based therapy (ABBT) to help LGBTQ+ adults with mild anxiety or depression worsened by the COVID-19 pandemic. 240 participants will either receive the therapy or standard care. The goal is to see if ABBT can reduce symptoms and improve social …

This study tests whether using a virtual reality headset (HypnoVR) can help reduce pain and anxiety during labor. Seventy women in Tunis will be randomly assigned to use the headset or receive standard care. Researchers will measure pain and anxiety levels before and after the in…

This study tests whether using a stress ball during a prostate biopsy can help reduce anxiety and pain. Researchers will enroll 66 men undergoing their first prostate biopsy. Participants will squeeze a stress ball during the procedure, and their pain and anxiety levels will be m…

This pilot study explores whether laughter yoga can reduce depression and anxiety in children with autism spectrum disorder (ages 8–12) and lower parenting stress for their parents. 66 families will either take part in laughter yoga sessions or be placed on a waiting list. The st…

This study tests whether a device called transcutaneous auricular vagus nerve stimulation (TaVNS) can reduce anxiety and distress in healthcare workers. Participants wear special earbuds that send gentle vibrations to stimulate the vagus nerve. Researchers will also use brain sca…

This study tests an online cognitive therapy program, guided by a therapist, to help colorectal cancer survivors who have finished treatment reduce their fear of the cancer returning. The program includes educational text, exercises, and videos. Researchers will compare it to sta…

This study planned to compare three different medications given as nose sprays to children aged 2 to 6 years who needed stitches for a cut. The goal was to see which one worked best for pain and anxiety during the procedure. However, the trial was withdrawn before any children we…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This study follows 300 Hispanic and Latino caregivers of relatives with memory problems or dementia. Participants complete daily surveys for three weeks at a time, plus follow-ups at six and twelve months, to track how their mood and stress change day-to-day. The goal is to ident…

This study observes 35 people in residential treatment for substance use disorders to measure behavioral rigidity—the tendency to get stuck in inflexible thinking patterns. Participants complete weekly questionnaires and have their therapy sessions analyzed for language patterns.…

This study looks at whether having a licensed counselor available can improve the mental well-being of medical residents (doctors in training). The researchers will measure changes in well-being, depression, and anxiety. 21 internal medicine residents from the University of Nevad…

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study tests a video-based mobile app designed to reduce mental health stigma and medical mistrust among Black adults with moderate to severe depression or anxiety. Participants watch personal stories from others with similar experiences. The goal is to see if this approach i…

This study tests whether a culturally tailored mobile health program can improve mental health and pregnancy outcomes in Black pregnant women. Half of the 150 participants will receive the program, which builds communication and self-advocacy skills and provides support. The goal…

This study looks at how jaw surgery changes not just your bite and appearance, but also your emotions, jaw muscles, and joint health. Researchers will follow 100 patients before and after surgery, using scans, muscle tests, and questionnaires to track these changes. The goal is t…

This study uses health records from about 100,000 people in Israel to see if past viral infections (like Epstein-Barr, COVID-19, or herpes) increase the risk of developing mental illnesses such as depression, anxiety, bipolar disorder, or schizophrenia. It also looks at whether i…

This study looks at whether certain slow brain waves in the prefrontal cortex can be a sign of social anxiety. Researchers will measure brain activity in 30 people with social anxiety disorder while they wait to give a speech. The goal is to better understand the brain's role in …

This study tests an 8-week school program called INSPIRE, designed to help Indonesian teenagers aged 13-15 learn about mental health, build resilience, and reduce symptoms of depression and anxiety. Trained school counselors deliver the program using lesson plans and activities, …

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study aimed to see if a drug called LY-2940094 could protect healthy adults from developing depression- or anxiety-like symptoms after stress. Researchers planned to give the drug to participants and then measure their brain responses to rewards and fear. However, the trial …

This study interviews 18 physiotherapists in private practice to understand how they screen for anxiety and depression in patients with chronic neck, shoulder, and low back pain. The goal is to identify what helps or hinders these mental health checks. The study does not test any…