Could a brain chemical blocker prevent Stress-Linked depression?
NCT ID NCT06786637
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aimed to see if a drug called LY-2940094 could protect healthy adults from developing depression- or anxiety-like symptoms after stress. Researchers planned to give the drug to participants and then measure their brain responses to rewards and fear. However, the trial was withdrawn before any volunteers were enrolled, so no data was collected.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Nociceptin Receptor Antagonist (LY-2940094)
- What this could lead to
- If successful, this research could point toward a new way to prevent stress-triggered depression or anxiety by targeting the brain's N/OFQ system.
- What could go wrong
- The study was withdrawn before enrolling anyone, so no results exist. It was also a small, early-phase mechanistic study in healthy volunteers, not patients, so any real-world treatment would be far off.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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