Mclean Hospital

This study tests whether adding five extra services—like peer support, digital outreach, and group therapy—to standard care helps people with early psychosis stay in treatment longer. About 350 participants will either receive standard care or the enhanced program. Researchers wi…

This study tests whether MitoQ, an antioxidant supplement, can improve thinking and memory in people with early schizophrenia who have signs of mitochondrial dysfunction. Researchers will give 50 participants either MitoQ or a placebo daily for 12 weeks, alongside their usual med…

This study tests whether adding magnesium vitamin B6 to usual treatment can reduce depression, anxiety, and stress in people experiencing their first episode of bipolar I disorder. Forty adults aged 18-50 will take either the supplement or a placebo three times daily for four wee…

This pilot study tests a new one-day treatment for people with borderline personality disorder (BPD) who have suicidal thoughts. It combines a medication called D-cycloserine with up to 20 short sessions of transcranial magnetic stimulation (TMS) over 12 hours. The study enrolls …

This study tests a computer-based training program called CBM-I for adults with obsessive-compulsive disorder (OCD). The training aims to change how people interpret situations, which may reduce OCD symptoms. Participants will be randomly assigned to either the training or a cont…

This study tests whether taking D-serine (an amino acid) before transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. Sixty adults with major depressive disorder will receive either D-serine or a placebo before TMS sessions for six weeks. Th…

This phase 2 trial tests a custom high-CBD sublingual product against a placebo in 30 women with endometriosis. Over 12 weeks, researchers will measure changes in pain and quality of life. The goal is to see if cannabinoids can help manage symptoms where few proven options exist.

This phase 2 trial is testing a custom, THC-free CBD product to see if it can reduce anxiety and depression in people with bipolar disorder. Twenty-five adults with bipolar I or II who have at least moderate anxiety will take the CBD daily for 4 weeks. Researchers will measure ch…

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people with early bipolar disorder. Fifty participants will follow either the ketogenic diet or standard dietary guidelines for 12 weeks. Researchers will me…

This study is observing 400 adults with OCD who are receiving exposure therapy. Researchers will use machine learning to analyze self-reports, behavior, and physiological data from therapy sessions. The goal is to identify which mechanisms lead to better outcomes, so therapy can …

This study looks at how a mindfulness app might help teenagers (ages 13-18) who tend to ruminate—getting stuck in repetitive negative thoughts. Participants will be randomly assigned to use the app or a control activity, and will have brain scans and cognitive tests before and af…

This study looks at how stress and a sense of control affect brain activity in teenage girls with major depression. Researchers will use brain scans and smartphone surveys to understand these connections. The goal is to learn more about depression, not to test a new treatment. Ab…

This study tests an experimental drug to see if it can fix brain patterns linked to avoiding rewards in people with major depression or anxiety. About 112 unmedicated adults will have brain scans and do decision-making tasks. The goal is to understand how the drug works, not to c…

This study aims to understand how a specific type of brain stimulation, called continuous theta-burst stimulation (cTBS), affects brain activity in people with depression. Researchers will give participants a single dose of one of four FDA-approved drugs (or a placebo) that eithe…

This study aims to develop a new tool to measure outcomes in substance use disorder treatment. Researchers will interview patients, caregivers, and clinicians to identify key themes and create a questionnaire. The goal is to provide a more accurate way to assess treatment effecti…

This study explores whether a non-invasive magnetic brain stimulation technique (TMS) can temporarily improve how quickly people with psychotic disorders (like schizophrenia or bipolar) solve problems. About 95 participants will do thinking tasks and get brain scans before and af…

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to understand how hallucinations work in people with schizophrenia or schizoaffective disorder. Researchers will stimulate a specific brain circuit and measure changes in brain connectivity and…

This study uses brain imaging to explore how severe childhood stress may cause chemical changes in the brain that increase depression risk. Researchers will scan the brains of 160 women aged 20-32, some with a history of childhood adversity and some without. The goal is to unders…

This study tests whether a radio-wave sensor placed in the home can measure sleep, movement, and walking speed in 40 people with mild cognitive impairment or mild Alzheimer's who are taking nicotinamide riboside (a form of vitamin B3). The goal is to find digital biomarkers that …

This study looks at how teen girls with a family history of depression respond to stress compared to those without. Researchers will use brain scans, smartphone surveys, and smartwatches to track stress reactions in real time. The goal is to find early warning signs that could le…

This study investigates how a brain chemical system called nociceptin/orphanin FQ relates to major depression. Researchers will use PET and MRI scans, along with behavioral tasks, to examine brain activity and decision-making in people with current or past depression. The goal is…

This study looks at how parents' tendency to see threats in everyday situations (interpretation bias) may influence their children's anxiety. Researchers will have 300 parents of children aged 7-12 use a smartphone app for four weeks to practice thinking less anxiously. The goal …