Mclean Hospital

This study is testing whether adding five extra support elements to standard early psychosis care helps young adults stay engaged in treatment. The enhanced program includes peer support, family therapy, digital outreach, care coordination, and cognitive training. Researchers wil…

This study is testing whether adding a dietary supplement called D-serine to standard magnetic brain stimulation (TMS) therapy works better for treating depression than TMS alone. Researchers will compare depression symptoms in about 60 adults receiving either the combination or …

This study is testing if following a ketogenic diet (high-fat, very low-carb) alongside usual treatment can help people recently diagnosed with bipolar disorder or schizoaffective disorder. Researchers will measure if the diet changes how the brain uses energy and if it improves …

This study is testing if a daily antioxidant supplement called MitoQ can improve thinking skills like memory and focus in people with early schizophrenia. Researchers will enroll 100 people, but only 50 with a specific blood marker of 'mitochondrial dysfunction' will take either …

This study is testing if adding an over-the-counter magnesium and vitamin B6 supplement to standard treatment can help reduce symptoms of depression, anxiety, and stress in adults recently diagnosed with bipolar I disorder. Researchers will compare the supplement to a placebo (in…

This study aims to understand how a specific brain circuit involved in making decisions (like approaching rewards or avoiding threats) works differently in people with depression or anxiety. Researchers will give an experimental drug to 112 unmedicated participants and use MRI br…

This study aims to understand how severe stress in childhood affects the brain and increases the risk for depression later in life. Researchers will use brain scans and other tests on 160 young women to look for specific chemical and functional changes linked to past trauma. The …

This study aims to understand if a non-invasive magnetic brain stimulation technique can change how quickly people with psychotic disorders think and solve problems. Participants with schizophrenia, bipolar disorder, or schizoaffective disorder will perform thinking tasks and hav…

This study aims to understand how anxious thinking patterns in parents might be passed on to their children. Researchers will test whether a smartphone app that teaches parents to interpret situations in less threatening ways can change parenting behaviors and reduce anxious thin…

This study aims to understand exactly how exposure therapy helps people with obsessive-compulsive disorder (OCD). Researchers will monitor 400 adults receiving this therapy, tracking their symptoms, body responses, and session details. By using machine learning, they hope to iden…

This study aims to understand the brain circuits involved in hallucinations experienced by people with schizophrenia. Researchers will use a non-invasive magnetic stimulation technique (TMS) and brain scans (MRI) on 68 participants to measure how specific brain connections change…

This study aims to understand how stress affects the brain and body in teenage girls who have a parent with depression, compared to those who don't. Researchers will track 148 girls aged 13-15 over 18 months using brain scans, smartwatches, and phone surveys to see how they respo…

This study aims to see if a small, contactless device placed in the bedroom can detect subtle changes in sleep patterns, walking speed, and daily activity in people with mild memory problems or early Alzheimer's disease. About 40 participants will have the device monitor them at …

This study aims to understand how depression affects the brain and decision-making. Researchers will use MRI and PET brain scans, along with blood tests and behavioral tasks, on 228 adults with current or past depression. The goal is to identify brain patterns that might predict …