Mclean Hospital

This study looks at whether adding five extra services—like peer support, digital outreach, and family therapy—to standard coordinated specialty care helps people with early psychosis stay in treatment longer. About 350 participants will either receive standard care or the enhanc…

This study is testing if a daily antioxidant supplement called MitoQ can improve thinking skills like memory and focus in people with early schizophrenia. Researchers will enroll 100 people, but only 50 with a specific blood marker will take either MitoQ or a placebo pill for 12 …

This study tests whether a ketogenic diet (high fat, low carb) can improve brain energy and reduce psychiatric symptoms in people recently diagnosed with bipolar I or schizoaffective disorder. Fifty adults aged 18-45 will follow the diet for 12 weeks alongside their usual care. T…

This study tests whether taking magnesium and vitamin B6 alongside standard treatment can reduce symptoms of depression, anxiety, and stress in people who have recently been diagnosed with bipolar I disorder. About 40 adults aged 18 to 50 with a first episode in the last 10 years…

This study tests a custom, hemp-derived CBD product against a placebo to see if it can reduce pain and improve quality of life in people with endometriosis. Researchers will track pain levels and other symptoms over 12 weeks. The goal is to provide much-needed evidence on whether…

This study tests a special high-CBD product to see if it helps reduce anxiety and depression in people with bipolar disorder. About 25 adults with stable bipolar disorder and moderate anxiety will take CBD for 4 weeks. Researchers will measure changes in anxiety and mood using st…

This early-phase study tests whether adding D-serine (an amino acid) to transcranial magnetic stimulation (TMS) can improve depression symptoms more than TMS alone. About 60 adults with major depressive disorder will receive 30 treatment sessions. The goal is to see if the combin…

This study tests an experimental drug to see if it can change how the brain processes decisions involving reward or risk in people with major depression or anxiety disorders. Participants will undergo brain scans and complete behavioral tasks while taking the drug or a placebo. T…

This study aims to understand how continuous theta-burst stimulation (cTBS), a form of transcranial magnetic stimulation, changes brain activity in people with depression. Researchers will test whether cTBS works by weakening overactive brain connections or by boosting the brain'…

This study aims to develop a new questionnaire to measure the real-world consequences of substance use disorder. Researchers will interview 50 people, including patients, their loved ones, and healthcare providers, to identify the most important outcomes. The goal is to create a …

This study looks at how stress affects the brain, body, and behavior in teenage girls who have a parent with depression. Researchers will use brain scans, smartwatches, and smartphone surveys to track stress responses in real life. The goal is to find early signs that could help …

This study looks at whether a non-invasive brain stimulation technique called TMS can improve how quickly people with psychotic disorders (like schizophrenia or bipolar disorder) solve problems. About 95 participants will do thinking tasks and get brain scans before and after TMS…

This study looks at how a specific brain system (the nociceptin receptor) affects decision-making and stress in people with current or past major depression. Researchers will use brain scans (MRI and PET), blood and saliva tests, and computer tasks to understand these connections…

This study looks at whether teaching parents to interpret ambiguous situations less negatively can reduce anxiety in their children. Researchers will enroll 300 parent-child pairs (children ages 7-12). Parents will use a smartphone app for four weeks to practice thinking in a les…

This study looks at whether a mindfulness app can help teenagers (ages 13-18) who tend to ruminate—repetitively dwelling on negative thoughts. Participants will be randomly assigned to use the app or a control activity, and will have brain scans and cognitive tests before and aft…

This study aims to understand why exposure therapy helps some people with OCD but not others. Researchers will track 400 adults with OCD during therapy sessions, measuring things like heart rate and self-reported feelings. The goal is to find out which parts of therapy work best …

This study uses a safe, noninvasive technique called transcranial magnetic stimulation (TMS) to understand how hallucinations happen in people with schizophrenia or schizoaffective disorder. Researchers will stimulate a specific brain circuit and measure changes in brain activity…

This study aims to find digital markers of brain energy changes in people with mild cognitive impairment or early Alzheimer's. Researchers will use passive home sensors to measure sleep, movement, and walking speed over 12 weeks. Participants take a daily supplement called nicoti…

This study aims to understand how severe stress in childhood affects the brain and leads to depression in some people. Researchers will use brain scans and other tests to look at chemical and functional differences in the brains of 160 young women who experienced childhood advers…