Could a single day of TMS plus a pill ease suicidal thoughts in BPD?

NCT ID NCT07460947

Recruiting now Symptom relief Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This pilot study tests a new one-day treatment for people with borderline personality disorder (BPD) who have suicidal thoughts. It combines a medication called D-cycloserine with up to 20 short sessions of transcranial magnetic stimulation (TMS) over 12 hours. The study enrolls 20 adults and aims to see if the treatment is acceptable, feasible, and whether it improves symptoms and brain activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: D-cycloserine and transcranial magnetic stimulation (TMS)
What this could lead to: If it works, this could point toward a rapid, one-day treatment to reduce suicidal thoughts in people with borderline personality disorder.
What could go wrong: This is a very small, early-phase pilot study (20 people) testing feasibility first. It may not show clear benefits, and the effects might not last.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

borderline personality disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BORDERLINE PERSONALITY DISORDER (BPD)

Contacts and locations

Locations

McLean Hospital
RECRUITING

Belmont, Massachusetts, 02478, United States

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Other studies related to the condition(s) this trial covers.