Brain scans reveal new clues to Depression's inner workings
NCT ID NCT05630963
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates how a brain chemical system called nociceptin/orphanin FQ relates to major depression. Researchers will use PET and MRI scans, along with behavioral tasks, to examine brain activity and decision-making in people with current or past depression. The goal is to better understand depression and identify potential new treatment targets.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this research could help identify new targets for treating depression beyond current medications.
What could go wrong
This is an observational study, not a treatment trial. It is early-stage and may not lead to direct clinical benefits.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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McLean Hospital
RECRUITINGBelmont, Massachusetts, 02478, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••