Mclean Hospital

This study tests whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can improve brain energy and reduce stress in people with mild memory problems or early Alzheimer's. Researchers will measure changes in brain chemistry and thinking skills over time. …

This early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who had significant anxiety or agitation. The goal was to see if it could reduce these behavioral symptoms safely. The stud…

This study looks at how low field magnetic stimulation changes brain activity in people aged 60 and older with bipolar depression. Forty participants will have brain scans before and after real or fake treatment on two separate days. The goal is to understand the brain effects of…

This study was designed to see if a drug called LY-2940094 could protect healthy people from developing depression or anxiety after stress. Researchers planned to measure brain responses to rewards and fear using tasks and questionnaires. However, the study was withdrawn before a…

This study looks at how people who have had major depression in the past make decisions when faced with choices that involve risk or reward. Researchers use brain scans (MRI) and computer tasks to understand which brain areas are involved. The goal is to predict if depressive sym…

This study was designed to test whether a drug called lorcaserin could help people with cocaine dependence by rebalancing serotonin in the brain. Researchers planned to use brain scans to see if the drug reduced cravings and impulsivity. However, the study was withdrawn before en…

This study looks at how childhood abuse and neglect affect the brain in women with post-traumatic stress disorder (PTSD) or dissociative identity disorder (DID). Researchers will use brain scans (MRI) and thinking tests to find links between trauma and symptoms like feeling detac…