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Could a sleep medication curb nicotine cravings?

NCT ID NCT03999099

Ongoing Symptom relief Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study tests whether suvorexant, a drug used for insomnia, can reduce nicotine cravings and withdrawal symptoms in daily smokers. Participants, who smoke at least 5 cigarettes a day and are nicotine-dependent, will receive either a low or high dose of suvorexant or a placebo. The goal is to see if blocking the brain chemical orexin can make it easier to resist smoking.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
suvorexant, a drug that blocks orexin, a brain chemical involved in wakefulness and craving
What this could lead to
If it works, this could point toward a new way to help people quit smoking by reducing cravings and withdrawal symptoms.
What could go wrong
This is an early-phase trial with only 45 participants, so results may not apply broadly. Suvorexant can cause drowsiness, which might limit its use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NICOTINE DEPENDENCE

Contacts and locations

Locations

  • McLean Hospital

    Belmont, Massachusetts, 02478, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.