NICOTINE DEPENDENCE

This study tests whether a common stop-smoking medication (varenicline) plus financial incentives can help adults aged 18-40 who use both e-cigarettes and cannabis quit vaping. All 105 participants will receive the drug and rewards for 12 weeks. Researchers will also track how ca…

This study tests whether starting nicotine replacement therapy (patches, gum, or lozenges) at a specific time in the menstrual cycle helps women quit smoking. About 1,200 women who smoke daily and have regular periods will be assigned to start their quit attempt during the follic…

This study tests whether e-cigarettes or nicotine pouches help adult smokers reduce their cigarette use. 256 participants who smoke will be given one of these products for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they smoke a…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the …

This study tests whether the medication varenicline can help adults quit using e-cigarettes. Researchers will compare varenicline to a placebo in 326 people who vape daily. The main goal is to see if more participants can stop vaping for at least a week by the 12-week mark, with …

This study tests whether a non-invasive brain stimulation technique called TMS can help people with mental illness quit smoking. Forty daily smokers with psychiatric conditions will receive either TMS or standard care. The goal is to see if TMS is practical and effective in real-…

This study tests a behavioral program called QuitVaping, which combines counseling sessions with text message support, to help teenagers aged 14-18 quit vaping. About 400 participants who vape nicotine at least weekly will be randomly assigned to either the QuitVaping program or …

This study tests a smartphone app called ACT on Vaping to help young adults (ages 18-30) quit using e-cigarettes. The app uses behavioral therapy to help users recognize triggers and build skills to stop vaping. About 1,178 participants will use the app or a control, and research…

This study tests a social media program called Quit the Hit Toolkit to help teens and young adults stop vaping. Coaches are trained to lead small support groups for 5 weeks. The goal is to see if this approach is practical and helpful for quitting nicotine.

This study tests whether a personalized exercise program can help smokers who are afraid of bodily sensations (like a racing heart) quit smoking. 360 adults will take part at YMCA locations. The goal is to see if exercise reduces smoking relapse and helps people stay smoke-free f…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults reduce or quit smoking and vaping. About 406 participants in Switzerland and Türkiye will be randomly assigned to the program or a control group. The program includes ei…

This early-phase study tests whether a device that delivers specific smells can reduce cigarette cravings and help people stop smoking. About 132 smokers will use a smartphone app with or without the scent device for a week, then report cravings and quit attempts. The goal is to …

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study tests whether a type of talking therapy called Acceptance and Commitment Therapy (ACT) can help people with schizophrenia quit smoking and reduce their psychotic symptoms. Researchers will use brain scans (fMRI) to see if the therapy changes how the brain responds to c…

This pilot study is testing whether a high-dose nicotine patch can reduce pain and the need for opioid painkillers in male smokers who are having chest surgery. The patch is given before and after surgery. The study will track how much pain medication participants use. It include…

This early-stage study at Johns Hopkins is testing whether cannabidiol (CBD) can reduce stress and nicotine withdrawal symptoms in people who smoke. Ninety healthy smokers will receive CBD and then be exposed to stress while researchers measure their mood, heart rate, and stress …

This study looks at how nicotine changes brain function in people with and without major depressive disorder (MDD). Researchers will give 620 non-smokers either a nicotine patch or a placebo and then scan their brains using MRI. Participants will also answer questions about their…

This study is developing new MRI techniques to better understand how drug addiction changes the brain. Researchers will scan 1,000 healthy adults, smokers, and drug users to improve imaging methods. The goal is to create tools that can reveal the brain's structure and function in…

This study aims to find the smallest amount of nicotine that smokers find rewarding or addictive. Researchers will test different nicotine doses in 45 adult smokers to see which dose they can identify and prefer. The goal is to better understand how addiction develops, which coul…

This study looks at young adults aged 18 to 25 who use both tobacco/nicotine products and cannabis. Researchers want to understand what happens to cannabis use when participants try to quit nicotine. All participants receive remote counseling and incentives to stop using nicotine…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers. Researchers will also study how it affects thinking and reward processing in non-smokers. The goal is to understand if blocking a brain c…

This study looks at how the body handles synthetic nicotine compared to natural nicotine from tobacco. Eighteen experienced e-cigarette users will vape three different nicotine blends in a controlled setting. Researchers will measure nicotine levels in the blood, heart effects, c…

This study looks at how the drug propranolol and nicotine patches, alone or together, change brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers will undergo brain scans while viewing these cues. The goal is to understand the brain mechanisms b…

This study aims to understand if relighting a cigarette (smoking it in parts) produces more harmful chemicals than smoking it all at once. Researchers will observe 30 smokers who already relight their cigarettes, measuring their smoking habits and collecting cigarette butts. No t…