NICOTINE DEPENDENCE

This study tests whether combining medication (varenicline or nicotine patch) with extra support can help people with HIV quit smoking. Smoking is especially harmful for those with HIV, shortening life more than the virus itself. The trial will enroll 340 adults with HIV who smok…

This study tests whether varenicline, a medication already used to help people stop smoking, can help adults quit using e-cigarettes (vaping). About 326 people who vape daily will receive either varenicline or a placebo for 12 weeks, and researchers will check if they have stoppe…

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people stop smoking cigarettes. Fifty adult smokers will use the pouches for 4 weeks instead of smoking. Researchers will track how many people fully switch and how much their smoking drops. The goal is…

This study tests if a non-invasive brain stimulation technique called rTMS can help people with mental illness quit smoking. Forty daily smokers with a psychiatric condition will either receive rTMS or standard care. Researchers will also talk to patients and doctors to see if ad…

This study looks at whether e-cigarettes or nicotine pouches can help adults who smoke cut down on cigarettes. About 256 smokers will try one of these products for 4 weeks, with different flavors and nicotine strengths. Researchers will track how many cigarettes they smoke and ho…

This study looks at whether starting a quit attempt during the first half of the menstrual cycle (follicular phase) helps women stop smoking more successfully than starting during the second half (luteal phase) or without cycle timing. About 1,200 women who smoke daily and have r…

This study tests a new way to help people stop smoking by using pleasant smells to reduce cigarette cravings. Participants will use a smartphone app that guides them to sniff specific scents when they feel the urge to smoke. The goal is to see if this simple, drug-free method mak…

This study tests a program called QuitVaping, which combines coaching and text message support, to help teens ages 14-18 quit vaping. About 400 teens who vape at least weekly will be randomly assigned to either the QuitVaping program or standard advice and resources. The main goa…

This study tests a free, internet-based program that uses mindfulness and behavioral strategies to help adults in Switzerland and Türkiye reduce or quit smoking and vaping. About 406 participants will be randomly assigned to the program or a control group. The program includes ei…

This study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking while in the hospital. About 60 adults aged 18-65 will be randomly …

This study looks at whether a high-dose nicotine patch, placed on the skin before and after chest surgery, can help reduce pain and the need for strong painkillers in male smokers who have temporarily stopped smoking. About 80 men aged 18-75 who smoke regularly and are having lun…

This study looks at whether cannabidiol (CBD) can reduce stress and withdrawal symptoms in people who smoke cigarettes. About 90 smokers will take CBD and then be exposed to stress. Researchers will measure mood, heart rate, and stress hormones to see if CBD helps. Some participa…

This study tests a social media program called the Quit the Hit Toolkit to help teens and young adults stop vaping. Researchers will train coaches to lead 5-week online support groups for 60 participants aged 13-21. The goal is to see if the program is practical and well-liked in…

This study looks at how the body handles different types of nicotine in e-cigarettes. Eighteen experienced vapers will try three forms: natural, synthetic, and a mix. Researchers will measure nicotine levels in the blood, heart effects, and how much people vape, as well as cravin…

This study aims to develop better MRI techniques to see how drug addiction changes the brain. Researchers will scan the brains of up to 1,000 adults, including smokers, non-smokers, and people who use drugs or not. The goal is to improve our understanding of addiction and pave th…

This study looks at how a beta-blocker (propranolol) and nicotine patches, alone or together, affect brain activity and cravings when smokers see smoking-related cues. Eighty daily smokers aged 21-60 will take part, but they won't try to quit or take the medications long-term. Th…

This study looks at how suvorexant, a medicine used for insomnia, changes brain function in people who smoke or vape daily and in non-smokers. Researchers want to see if it can reduce cravings and help understand addiction. About 140 smokers and 80 non-smokers will take part, wit…

This study looks at what happens when smokers relight cigarettes instead of smoking them all at once. Researchers will measure chemicals in the smoke and how people puff. The goal is to see if relit cigarettes produce more harmful substances. The study involves 30 smokers who alr…

This study looks at how the amount of nicotine and how fast it enters the body affects a person's desire to smoke and the drug's addictive potential. Researchers will give nicotine through an IV to 70 daily smokers, mimicking the way cigarettes deliver nicotine. The goal is to un…