NICOTINE DEPENDENCE

This study is testing whether a special behavioral program, combined with text message support, is better than basic education at helping teenagers quit vaping nicotine. About 400 teens who vape weekly and want to quit will be randomly assigned to receive either the full program …

This study is testing whether tobacco-free nicotine pouches can help people switch from smoking cigarettes. Researchers will give 50 adult smokers either low or high nicotine pouches to use for 4 weeks instead of cigarettes. They'll track how many people completely switch, reduce…

This study is testing whether a non-invasive brain stimulation treatment can help people with mental health conditions quit smoking. It compares magnetic stimulation therapy to standard treatment using nicotine patches and counseling. The research aims to see if this new approach…

This study is testing if a prescription medication called varenicline, which helps people quit smoking cigarettes, is also effective for helping adults quit using e-cigarettes. Researchers will randomly assign 326 adults who vape daily to receive either the real medication or a p…

This study aims to find out if switching to e-cigarettes or oral nicotine pouches helps adults who smoke reduce their cigarette use. Researchers will give 256 participants one of these products for 4 weeks, testing different flavors and nicotine strengths. The main goal is to see…

This study aims to improve smoking cessation treatments specifically for people living with HIV, who smoke at higher rates and have more difficulty quitting than the general population. Researchers will test whether personalizing medication choices based on how a person's body pr…

This study is testing if starting a quit attempt during a specific phase of a woman's menstrual cycle makes it easier to stop smoking. It will enroll 1200 women who smoke daily and want to quit. Participants will be randomly assigned to start their quit attempt in one of two cycl…

This study is testing if a high-dose nicotine patch can help control pain in men who smoke and are having chest surgery. The goal is to see if the patch reduces the need for strong opioid painkillers after the operation, which can have bad side effects. It's a small pilot study w…

This study aims to create and test new, advanced brain scanning techniques to see how drug addiction changes the brain. Researchers will scan the brains of up to 1,000 adults, including both people who use drugs and those who don't, to compare the differences. The goal is to deve…

This study aims to understand how different amounts and speeds of nicotine delivery affect both the rewarding 'high' and the relief from smoking cravings. Researchers at Yale will give 70 smokers controlled intravenous nicotine doses that mimic smoking, while they puff on a nicot…

This study aims to understand if relighting a cigarette produces more harmful chemicals than smoking it without stopping. Researchers will observe 30 adult smokers who regularly relight cigarettes, measuring the smoke they produce and asking about their experience. The goal is to…

This early-stage study aims to understand if the compound CBD (cannabidiol) can help people who smoke cigarettes better manage stress and the cravings that come with nicotine withdrawal. Researchers at Johns Hopkins will give 90 daily smokers different doses of CBD or a placebo, …

This study aims to understand if nicotine made in a lab (synthetic) acts the same in the body as nicotine from tobacco. Researchers will have experienced e-cigarette users vape different types of nicotine. They will then measure how much nicotine gets into the blood, its effects …

This study aims to understand how a prescription sleep medication called suvorexant affects the brain activity related to smoking addiction. Researchers will give the drug to daily smokers and use brain scans to see if it reduces cravings triggered by smoking cues and changes how…