Nicotine pouches may quiet the Brain's craving for cigarettes
NCT ID NCT07698470
First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time
Summary
This study looks at whether a single 6 mg oral nicotine pouch can lower cigarette cravings and dampen brain activity triggered by smoking-related images. Adults who smoke and are moderately to highly dependent on nicotine will use the pouch after going without nicotine overnight. Researchers will measure changes in craving and prefrontal brain responses using a light-based brain scanner.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- oral nicotine pouch (6 mg)
- What this could lead to
- If it works, this could support oral nicotine pouches as a harm-reduction tool to help adults who smoke reduce cigarette cravings.
- What could go wrong
- This is a small, early-stage study with only 45 participants, so results may not apply broadly. The effect is measured over a single session, not long-term quitting success.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Southern California - 3641 Watt Way (HNB B22)
RECRUITINGLos Angeles, California, 90089, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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