CBD put to the test: could it curb cravings and calm nerves in smokers?

NCT ID NCT07001930

Recruiting now Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This early-stage study at Johns Hopkins is testing whether cannabidiol (CBD) can reduce stress and nicotine withdrawal symptoms in people who smoke. Ninety healthy smokers will receive CBD and then be exposed to stress while researchers measure their mood, heart rate, and stress hormones. The goal is to see if CBD can make quitting easier by easing the unpleasant effects of withdrawal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Epidiolex (cannabidiol, CBD)
What this could lead to: If it works, this could point toward a way to use CBD to help people quit smoking by reducing stress and withdrawal symptoms.
What could go wrong: This is an early Phase 1 study with only 90 people, so results may not apply broadly. CBD may not reduce stress or withdrawal better than a placebo.

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Conditions

The condition(s) this trial relates to.

nicotine dependence red-green color blindness Tobacco Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CBD NICOTINE DEPENDENCE STRESS TOBACCO SMOKING

Contacts and locations

Locations

Behavioral Pharmacology Research Unit
RECRUITING

Baltimore, Maryland, 21224, United States

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