E-Cigs vs nicotine pouches: which helps smokers quit best?

NCT ID NCT06077240

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether e-cigarettes or nicotine pouches help adult smokers reduce their cigarette use. 256 participants who smoke will be given one of these products for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they smoke and how often they use the alternative product.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: e-cigarettes and oral nicotine pouches
What this could lead to: If successful, this study could show which non-combustible nicotine products and features (like flavor and nicotine level) best help smokers cut down on cigarettes.
What could go wrong: This is a small, short-term study (4 weeks) focused on behavior, not long-term health outcomes. Results may not apply to all smokers, and switching to these products still carries health risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NICOTINE DEPENDENCE SMOKING SMOKING BEHAVIORS

Contacts and locations

Locations

Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

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