SMOKING

This study tests whether giving smokers a choice of e-cigarette flavors (tobacco, menthol, mint, or other) helps them stop smoking regular cigarettes. About 1,280 adult smokers will use a provided e-cigarette device for 13 weeks, and researchers will check who stays away from cig…

This study tests whether offering a choice of e-cigarettes, nicotine pouches, or nicotine patches helps people with HIV stop smoking tobacco. About 972 participants in Switzerland will receive their preferred product free for 6 months, plus standard care. The main goal is to see …

This study tests whether adding financial coaching to standard smoking cessation counseling helps low-income smokers quit. 602 participants will receive either standard counseling or integrated financial-smoking counseling, plus nicotine patches. The goal is to see if addressing …

This study tests a program called QuitAid, where pharmacists coach rural smokers on quitting. About 768 participants from Appalachia will get nicotine patches, and some will also get lozenges, text support, or phone counseling. The goal is to see which combination works best and …

This study tests whether e-cigarettes or nicotine pouches help adult smokers reduce their cigarette use. 256 participants who smoke will be given one of these products for 4 weeks, with different flavors and nicotine levels. Researchers will track how many cigarettes they smoke a…

This study tests whether paramedics in rural areas can help smokers who aren't ready to quit by offering a text-based program called Take a Break, along with nicotine lozenges. The program includes a two-week smoke-free challenge and coaching calls. Researchers will track how man…

This study tests whether giving smokers a personalized quit plan based on their genes, health history, and biomarkers helps more people stop smoking than standard advice. About 850 smokers and their doctors from primary care clinics will take part. The goal is to see if tailored …

This study tests a 24-week community-based lifestyle program called Inspire HER for Black women aged 30-79 with heart, kidney, or metabolic conditions. The program provides health education, physical activity, and social support to improve heart health. Researchers will also comp…

This study tests a mobile app program to help smokers with cancer quit. Participants can choose their own quit schedule and receive supportive text messages. The goal is to see if this personalized approach leads to more people quitting compared to standard advice. The study invo…

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will take part in weekly physical activity, health education, and work with a coach and trainer. The goal is to see if the program improves heart health and reduces st…

This study tests whether using mobile health (mHealth) tools helps find early signs of oral cancer better than the usual visual exam in rural areas of Varanasi, India. Over 5,000 adults with risk factors like smoking, tobacco use, or age over 40 will be screened. The goal is to c…

This study will give low-dose CT scans to over 6,600 people in Taiwan who are at high risk for lung cancer due to heavy smoking, family history, or environmental exposures like air pollution. The goal is to see how many people agree to screening and how many lung cancers are foun…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This study tests a drug called brenipatide against a placebo to see if it can help adults who have recently quit smoking stay smoke-free. About 222 participants will receive injections for 24 weeks and be followed for 8 more weeks. The main goal is to see if more people remain ab…

This study tests Emotional Freedom Techniques (EFT), a stress-reduction method that involves tapping on specific body points, in smokers who have failed standard quit programs. Researchers want to see if EFT can improve quit rates by reducing anxiety and cravings. The trial enrol…

This study tests whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can help daily smokers quit. rTMS uses magnetic pulses to stimulate brain areas involved in addiction and decision-making. Forty participants will receive daily sessions f…

This study tests whether specific chest exercises can improve breathing, chest expansion, and exercise capacity in university students who smoke. Thirty smokers aged 18-24 will be split into two groups: one doing chest PNF techniques and the other doing chest mobility exercises. …

This study tests whether a smartphone app that uses augmented reality (AR) can help people quit smoking when used alongside standard quitline counseling. The app shows smoking-related cues to help users manage cravings. The trial will enroll 3,600 adult daily smokers and measure …

This study looks at whether a daily dose of kava can help smokers who want to quit. Researchers will check if kava makes it easier to stop smoking, reduces stress, and improves sleep. About 76 adults who smoke at least 5 cigarettes a day and want to quit will take part for 4 mont…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study tests whether a personalized approach to smoking cessation helps cancer patients quit. Researchers will use patients' clinical, genetic, and biomarker information to create tailored treatment plans. The study involves 112 participants and compares this precision treatm…

This study tests a digital coaching program that uses a chatbot to help people quit smoking. The program aims to boost motivation, educate about quitting tools, and create a personalized quit plan. Researchers will enroll 440 adult smokers and check if they have quit after 6 mont…

This pilot study tests whether an internet-based program teaching dialectical behaviour therapy skills can help adult smokers in Hong Kong quit or reduce smoking while also improving their psychological distress. Sixty participants will be randomly assigned to either the online s…

This study aims to understand why some people respond better to a brain stimulation treatment (rTMS) for smoking. Researchers will measure brain activity in 100 smokers aged 21-60 to see if emotional triggers affect treatment success. The goal is to personalize future therapies f…

This study looks at how smoking impacts the ability to perform everyday activities in young adults aged 18-30 who smoke. Researchers will measure walking distance, sit-stand repetitions, and balance, along with feelings of breathlessness and fatigue. The goal is to spot early sig…

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This study recruits 600 adults who want to quit smoking. Participants use a smartphone app to take photos of their environment when they smoke and at random times. Researchers use artificial intelligence to analyze these images and identify environmental triggers that lead to rel…

This study uses brain scans (fMRI) to see what happens in the brain just before a smoker lapses (takes a cigarette during a quit attempt). Researchers will have 150 smokers complete a task where they can delay smoking for money, while their brain activity and feelings are measure…

This study looks at whether adult smokers who switch to a heated tobacco device (called THS or TP18) have lower levels of harmful chemicals in their body compared to those who keep smoking regular cigarettes. About 108 smokers will be monitored over a week in a clinic and then at…

This study looks at whether the flavor of e-cigarettes helps smokers switch from regular cigarettes. 210 smokers who have tried to quit before will use fruit, tobacco, or menthol flavored e-cigarettes for 6 weeks. Researchers will track how many cigarettes they smoke and how sati…

This study looks at how gum disease and smoking change certain proteins in saliva. Researchers will collect saliva and check gum health in 116 people with and without periodontitis. The goal is to see if these proteins can help diagnose gum disease and understand smoking's role.

This study enrolls 40 healthy smokers to compare how addictive five new oral nicotine products are compared to their usual cigarettes and Nicorette gum. Participants will use each product in a clinic setting, and researchers will measure their feelings of liking and nicotine leve…

This study collects blood, airway, and urine samples from 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare samples to establish normal ranges and learn how genes change in lung disease. The goal is to better underst…

This pilot study at Memorial Sloan Kettering tests whether giving cancer patients an indoor air quality monitor helps them maintain a smoke-free home. Ten participants who smoke and are in a tobacco treatment program will use the monitor for about 60 days. Researchers will see if…