SMOKING

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This study tests if a mobile app that lets smokers with cancer choose their own quit plan and sends supportive messages can help them quit. About 1,448 smokers with cancer in Hong Kong will take part. Half will get the app and support, the other half will get standard advice. The…

This study is testing whether a simple indoor air quality monitor can help cancer patients who smoke keep their homes smoke-free. Ten patients from Memorial Sloan Kettering's Tobacco Treatment Program will use the device for two weeks and attend workshops. The goal is to see if t…

This study tests a program called Inspire HER for Black women aged 30-79 with heart, kidney, and metabolic health issues. The program offers health education, physical activity, and social support to help lower heart disease risk. Researchers will see if the program is practical …

This study looks at whether e-cigarettes or nicotine pouches can help adults who smoke cigarettes reduce their smoking. About 256 participants will try one of these products for 4 weeks, with different flavors and nicotine strengths. Researchers will track how many cigarettes the…

This study tests whether adding financial coaching to standard smoking cessation counseling helps people with low income quit smoking more successfully. About 600 smokers who earn less than 200% of the federal poverty level will be randomly assigned to receive either standard qui…

This study tests a pharmacist-delivered smoking cessation program called QuitAid for rural smokers in Appalachia. About 768 participants will receive nicotine patches and may also get text support, phone counseling, extra nicotine gum, or pharmacist coaching. The goal is to see w…

This study tests whether giving people with HIV a choice of nicotine replacement products (like e-cigarettes, nicotine pouches, or patches) helps them quit smoking tobacco. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either standard care…

This study tests whether giving cancer patients personalized recommendations to quit smoking—based on their genes, health history, and lab results—helps them stop more than standard care. About 112 patients and their doctors will take part. The goal is to see if this tailored app…

This study tests a drug called brenipatide to see if it helps adults who recently quit smoking stay smoke-free longer. About 222 participants will receive either the drug or a placebo for 24 weeks, with follow-up visits. The goal is to reduce the chance of starting smoking again.

This study looks at whether adult smokers who switch to a heated tobacco device (like a prototype called TP18) have lower levels of certain harmful chemicals in their body compared to those who keep smoking regular cigarettes. About 108 smokers will be monitored over a week, incl…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system (THS) experience fewer symptoms like coughing and shortness of breath, and see improvements in lung function and walking ability. The study will comp…

This study tests whether giving smokers a personalized treatment plan—based on their genes, health history, and other markers—helps them quit better than standard care. About 850 adult smokers from primary care clinics will take part. The goal is to see if this tailored approach …

This study is testing how well low-dose CT scans can find lung cancer early in people at high risk in Taiwan. It includes three groups: heavy smokers who have quit, people with a family history of lung cancer, and those exposed to pollution or other risks at work or home. About 6…

This study tests whether a smartphone app that uses augmented reality (AR) can help people stop smoking when used alongside standard quitline counseling. The app shows smoking-related cues to help users practice resisting cravings. About 3600 adult daily smokers will take part. T…

This study tests a friendly chatbot that uses motivational interviewing to help people stop smoking. The chatbot offers education, support, and a personalized quit plan. Researchers will check if it works by testing saliva for nicotine at 6 months. The study needs 440 adult smoke…

This study tests if Emotional Freedom Techniques (EFT), a type of tapping therapy, can help smokers who have failed standard quit programs. Researchers will enroll 40 people who have high anxiety, strong cravings, or low confidence about quitting. The goal is to see if EFT can im…

This study tests a new online program that teaches coping skills to help smokers quit and manage stress, anxiety, and depression. About 60 adult smokers in Hong Kong who want to stop smoking will try the program or get standard support. Researchers will check if the program is ea…

This study looks at whether a daily dose of kava can help smokers who want to quit. Researchers will check if kava makes it easier to stop smoking, reduces stress, and improves sleep. About 76 adult smokers will take kava and report their progress over several months.

This study looks at whether special chest exercises can improve lung function and exercise ability in university students who smoke. Researchers will compare two types of exercises in 30 students aged 18-24 who have smoked for at least 2 years. The goal is to see if these exercis…

This study tests whether a non-invasive brain stimulation technique called rTMS can help daily smokers quit. Researchers want to see if offering this treatment in a nicotine addiction clinic is practical and acceptable. About 40 participants will receive daily rTMS sessions for 3…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study looks at how gum health and smoking influence certain inflammatory proteins (inflammasomes) in saliva. Researchers will compare levels of these proteins in people with healthy gums, those with gum disease, and smokers. The goal is to see if these proteins can help diag…

This study looks at brain activity in people trying to quit smoking to understand why lapses happen. Researchers will use MRI scans to track changes in the brain right before a person smokes. The goal is to find patterns that could help predict and prevent relapse. About 150 adul…

This study looks at how addictive five new oral nicotine products are. About 40 healthy smokers, aged 21 to 60, will use the products in a clinic and report their feelings while researchers measure nicotine levels in their blood. The goal is to understand the products' abuse pote…

This study looks at how differences in brain reactions to emotional cues might affect how well a brain stimulation treatment (rTMS) works for people who smoke. Researchers will monitor safety and side effects in 100 smokers aged 21-60. The goal is to learn how to personalize trea…

This study tests a new way to help rural smokers who are not yet ready to quit. Paramedics will refer participants to a text-message program that encourages them to stop smoking. The goal is to see if this approach gets more people to engage and eventually quit.

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. Researchers will compare samples to establish normal ranges and learn how gene changes in airway cells may lead to disease. The…

This study explores how everyday environments influence smoking relapse. Researchers will have 500 adults who want to quit smoking take photos of their surroundings using a smartphone app. Artificial intelligence will analyze the images to identify environmental triggers. The goa…

This study looks at whether the flavor of e-cigarettes (fruit, tobacco, or menthol) helps people who smoke regular cigarettes switch to e-cigarettes. About 210 smokers who have tried to quit before will use flavored e-cigarettes for six weeks. Researchers will track how many ciga…