SMOKING

This study tests whether giving people with HIV a choice of nicotine replacement products (like e-cigarettes, nicotine pouches, or patches) helps them quit smoking tobacco. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either standard care…

This study tests whether giving cancer patients personalized recommendations to quit smoking—based on their genes, health history, and lab results—helps them stop more than standard care. About 112 patients and their doctors will take part. The goal is to see if this tailored app…

This study looks at whether adult smokers who switch to a heated tobacco device (like a prototype called TP18) have lower levels of certain harmful chemicals in their body compared to those who keep smoking regular cigarettes. About 108 smokers will be monitored over a week, incl…

This study tests whether a pharmacist-delivered coaching program called QuitAid helps rural smokers in Appalachia quit. About 768 participants will receive nicotine patches and may also get text support, phone counseling, or extra nicotine gum. The goal is to find the best combin…

This study tests a new medicine called brenipatide to see if it can help adults who have recently quit smoking avoid relapsing. About 222 participants will receive either the drug or a placebo for 24 weeks, and researchers will track who stays smoke-free using carbon monoxide tes…

This study tests whether a mobile app that sends personalized messages and lets smokers with cancer choose their own quit schedule can help them stop smoking more effectively than standard advice. About 1,448 smokers with cancer in Hong Kong will take part. The goal is to see if …

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will do weekly physical activity and health education, and work with a coach and community health worker. The goal is to see if the program improves heart health and r…

This study tests whether adding financial coaching to standard smoking cessation counseling helps people with low income quit smoking more successfully. About 600 smokers who earn less than 200% of the federal poverty level will be randomly assigned to receive either standard qui…

This study tests a program called Inspire HER, designed to help Black women improve their heart health through education, physical activity, and social support. Researchers will enroll 90 Black women aged 30-79 with heart, kidney, or metabolic conditions in the Birmingham, AL are…

This study looks at whether e-cigarettes or nicotine pouches can help adults who smoke cut down on cigarettes. About 256 smokers will try one of these products for 4 weeks, with different flavors and nicotine strengths. Researchers will track how many cigarettes they smoke and ho…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system (THS) experience fewer symptoms like coughing and shortness of breath, and see improvements in lung function and walking ability. The study will comp…

This study tests whether giving smokers a personalized treatment plan—based on their genes, health history, and other markers—helps them quit better than standard care. About 850 adult smokers from primary care clinics will take part. The goal is to see if this tailored approach …

This study is testing whether low-dose CT scans can find lung cancer early in over 6,600 people in Taiwan who are at high risk. Participants include heavy smokers who quit, people with a family history of lung cancer, and those exposed to pollution or cooking fumes. The goal is t…

This study tests an internet-based program that teaches skills to help adult smokers quit or cut down on smoking while also managing stress, anxiety, and depression. About 60 Hong Kong Chinese smokers who want to quit and feel psychological distress will take part. The program is…

This study tests a digital coach, called a chatbot, that uses motivational interviewing to help people quit smoking. The chatbot provides education, builds motivation, and creates a personalized quit plan. 440 adult smokers will use the chatbot and be followed for 6 months to see…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study tests if Emotional Freedom Techniques (EFT), a type of tapping therapy, can help smokers who have failed standard stop-smoking programs. Researchers will enroll 40 people who have high anxiety, strong cravings, or low confidence about quitting. The goal is to see if EF…

This study looks at whether special chest exercises can improve lung function and exercise ability in university students who smoke. Researchers will compare two types of exercises in 30 students aged 18-24 who smoke regularly. The goal is to see if these exercises can help count…

This study tests a non-invasive treatment called rTMS that uses magnetic pulses to stimulate brain areas linked to addiction and decision-making. About 40 daily smokers will receive daily sessions for 3 weeks, then weekly sessions for 3 more weeks. The goal is to see if offering …

This study looks at whether taking kava daily can help smokers who want to quit by reducing stress and improving sleep. About 76 adult smokers will take kava and be monitored for how well they stick with it, how much they smoke, and their stress and sleep quality. The goal is to …

This study tests whether a smartphone app that uses augmented reality can help people quit smoking when used alongside standard quitline counseling. About 3,600 adults who smoke daily will be asked to use the app and report their progress. The goal is to see if the app makes it e…

This study tests a new way to help rural smokers who are not yet ready to quit. Paramedics will refer participants to a text-message program that encourages them to stop smoking. The goal is to see if this approach gets more people to engage and eventually quit.

This study looks at whether a simple indoor air quality monitor can help cancer patients who smoke keep their homes smoke-free. Ten patients from Memorial Sloan Kettering's Tobacco Treatment Program will use the device for two weeks and attend workshops. The goal is to see if thi…

This study looks at how individual differences in brain reactions to emotional cues might affect how well a brain stimulation technique (rTMS) helps people quit smoking. Researchers will monitor 100 smokers aged 21-60 for safety and brain responses. The goal is to learn more, not…

This study looks at brain activity to understand why people who try to quit smoking often start again. Researchers will use MRI scans to watch changes in the brain right before a person smokes. The goal is to find patterns that could help predict and prevent relapse. About 150 ad…

This study looks at how likely people are to abuse five new oral nicotine products. Researchers will measure cravings and nicotine levels in 40 healthy smokers after they use the products. The goal is to understand the products' addiction potential, not to treat any disease.

This study explores how everyday environments influence smoking relapse. Researchers will have 500 adults who want to quit smoking take photos of their surroundings using a smartphone app. Artificial intelligence will analyze the images to identify environmental triggers. The goa…

This study collects blood, airway, and urine samples from up to 2,000 healthy volunteers and people with lung diseases like COPD and pulmonary fibrosis. The goal is to establish normal ranges and understand the genetic changes that lead to lung disease. Participants must be 18 or…

This study looks at whether the flavor of e-cigarettes (fruit, tobacco, or menthol) helps people who smoke regular cigarettes switch to e-cigarettes. About 210 smokers who have tried to quit before will use flavored e-cigarettes for six weeks. Researchers will track how many ciga…

This study looks at how gum disease and smoking change certain proteins (inflammasomes) in your saliva. Researchers will compare these proteins in people with healthy gums, those with gum disease, and smokers. The goal is to find a simple saliva test that could help diagnose gum …