New shot aims to keep Ex-Smokers from lighting up again

NCT ID NCT07223840

Recruiting now Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study tests a drug called brenipatide against a placebo to see if it can help adults who have recently quit smoking stay smoke-free. About 222 participants will receive injections for 24 weeks and be followed for 8 more weeks. The main goal is to see if more people remain abstinent from cigarettes with brenipatide than with placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brenipatide
What this could lead to: If it works, this could offer a new medication to help people who have quit smoking avoid relapsing.
What could go wrong: This is an early Phase 2 trial with only 222 participants, so results may not apply broadly. The drug may not prove more effective than placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING

Contacts and locations

Locations

2nd Affiliated Hospital Chongqing Medical University
RECRUITING

Chongqing, 400072, China
Adams Clinical Dallas
NOT_YET_RECRUITING

DeSoto, Texas, 75115, United States
Arch Clinical Trials
RECRUITING

St Louis, Missouri, 63141, United States
Beijing Anding Hospital - Affiliated Capital University of Medical Science
RECRUITING

Beijing, 100088, China
Beijing Chaoyang Hospital, Capital Medical University
RECRUITING

Beijing, 100020, China
Circle Clinical Research
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Coastal Carolina Research Center
RECRUITING

North Charleston, South Carolina, 29405, United States
Eastside Research Associates
RECRUITING

Redmond, Washington, 98052, United States
FutureSearch Trials of Dallas
RECRUITING

Dallas, Texas, 75251, United States
GTL Medical & Research Group
RECRUITING

Miami, Florida, 33173, United States
Health Research of Hampton Roads, Inc.
RECRUITING

Newport News, Virginia, 23606, United States
Higashi Shinjuku Clinic
RECRUITING

Tokyo, 169-0072, Japan
Hillcrest Medical Research
COMPLETED

DeLand, Florida, 32720, United States
K2 Medical Research ORLANDO
RECRUITING

Maitland, Florida, 32751, United States
Miyazaki RC Clinic
RECRUITING

Shinagawa-ku, 140-0001, Japan
North Georgia Clinical Research
RECRUITING

Woodstock, Georgia, 30189, United States
Revival Research Institute, LLC
RECRUITING

Dearborn, Michigan, 48126, United States
Rochester Clinical Research, LLC
RECRUITING

Rochester, New York, 14609, United States
Samoncho Clinic
RECRUITING

Shinjuku, 160-0017, Japan
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, 610072, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, 310016, China
Taizhou Hospital of Zhejiang Province
RECRUITING

Linhai, 317000, China
TecTum Research
RECRUITING

Hollywood, Florida, 33024, United States
The University of Hong Kong-Shenzhen Hospital
RECRUITING

Shenzhen, 518053, China
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77054, United States
The first affiliated hospital of Ningbo university
RECRUITING

Ningbo, 315010, China
Vector Clinical Trials
RECRUITING

Las Vegas, Nevada, 89128, United States
Woodland Research Northwest
RECRUITING

Rogers, Arkansas, 72758, United States

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