Scientists scan brains to catch smoking lapses before they happen

NCT ID NCT05572671

Recruiting now Knowledge-focused Sponsor: Penn State University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses brain scans (fMRI) to see what happens in the brain just before a smoker lapses (takes a cigarette during a quit attempt). Researchers will have 150 smokers complete a task where they can delay smoking for money, while their brain activity and feelings are measured. The goal is to understand why lapses happen, which could lead to better ways to prevent relapse.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could reveal brain patterns that predict a smoking lapse, pointing toward better strategies to help people quit smoking.
What could go wrong: This is an early-stage observational study, not testing a treatment. It may not find clear brain signals, and results may not apply to all smokers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Smoking Tobacco Use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING TOBACCO USE

Contacts and locations

Locations

The Pennsylvania State University
RECRUITING

University Park, Pennsylvania, 16870, United States

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Other studies related to the condition(s) this trial covers.