Hormone pill may help new mothers quit smoking for good

NCT ID NCT04783857

Recruiting now Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests whether taking progesterone pills can prevent new mothers from relapsing into cigarette smoking after childbirth. Researchers will enroll 171 women who recently quit smoking during pregnancy to see if the hormone helps them stay smoke-free and reduces secondhand smoke exposure for their babies. The trial also looks at differences in outcomes across racial and ethnic groups.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Progesterone 200 mg oral capsule
What this could lead to: If it works, this could offer a hormone-based option to help new mothers avoid smoking relapse, improving their health and reducing infants' exposure to secondhand smoke.
What could go wrong: This is a Phase 4 study with 171 participants, so results may not apply to all women. Progesterone can cause side effects like dizziness or mood changes, and the effect on long-term abstinence is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SMOKING are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Smoking Smoking Cessation Smoking Reduction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING SMOKING CESSATION SMOKING REDUCTION

Contacts and locations

Locations

University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.