New nicotine products put to the test: are they less addictive than cigarettes?

NCT ID NCT07132814

Recruiting now Knowledge-focused Sponsor: RAI Services Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study enrolls 40 healthy smokers to compare how addictive five new oral nicotine products are compared to their usual cigarettes and Nicorette gum. Participants will use each product in a clinic setting, and researchers will measure their feelings of liking and nicotine levels in the blood. The goal is to see if these products have lower abuse liability, which could help smokers switch to less harmful options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotine
What this could lead to: If successful, this could help understand which nicotine products have lower abuse potential, potentially guiding harm reduction strategies.
What could go wrong: This is a small, early-phase study (40 participants) measuring subjective effects and nicotine levels, not long-term addiction or health outcomes. Results may not reflect real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Smoking Tobacco Smoking Tobacco Use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SMOKING SMOKING BEHAVIORS TOBACCO SMOKING TOBACCO USE

Contacts and locations

Locations

Dr. Vince Clinical Research
RECRUITING

Overland Park, Kansas, 66212, United States

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