Can a pouch replace a cigarette? new study tests zyn as a smoking swap

NCT ID NCT06678789

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people switch from smoking cigarettes. Fifty smokers will get either low (3 mg) or high (6 mg) nicotine pouches to use for 4 weeks. Researchers will check if they stop smoking and how much they use the pouches instead.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Zyn nicotine pouches (3 mg or 6 mg nicotine)
What this could lead to
If it works, this could show that nicotine pouches are a practical way for people to stop smoking cigarettes, reducing harm from smoking.
What could go wrong
This is a small, early study with only 50 people. Nicotine pouches are still addictive and may not help everyone quit smoking. Results may not apply to all smokers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking nicotine dependence Smoking Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

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